51-80-9Relevant academic research and scientific papers
Method for preparing kakonein derivatives
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Paragraph 0025-0026, (2017/03/17)
The invention discloses a puerarin derivative preparation method. Puerarin derivative has the structural formula as shown in the specification, and the puerarin derivative is obtained by that puerarin reacts with CH2(R)2, wherein R is a tertiary amine gene. The puerarin derivative preparation method is characterized in that reaction is carried out under hydrochloric acid catalysis. Compared with the prior art, the puerarin derivative preparation method is characterized in that the yield of a puerarin derivative product can be obviously improved after the class of reaction adopts hydrochloric acid catalysis.
Siloxymethylamines as Aminomethylation Reagents for Amines Leading to Labile Diaminomethanes That can be Trapped as Their [Mo(CO)4] Complexes
Sharma, Hemant K.,Gonzalez, Paulina E.,Craig, Alexander L.,Chakrabarty, Sanchita,Metta-Maga?a, Alejandro,Pannell, Keith H.
, p. 7363 - 7366 (2016/05/24)
Compound Et3SiOCH2NMe2 transfers Me2NCH2 to R2NH (R2=Et2, PhMe, [Cr(η6-C6H5)(CO)3]Me, PhH) to form previously unknown diaminomethanes, Me2NCH2NR2 and, in the case of R2=PhH, the triamine Me2NCH2N(Ph)CH2NMe2. The diaminomethanes exhibit an unreported disproportionation to a mixture of (R2N)2CH2, (Me2N)2CH2, and Me2NCH2NR2, which can be trapped as their [Mo(CO)4(diamine)] complexes. Whereas PhMeNCH2NMe2 is a labile material, the metal-substituted ([(η6-C6H5)Cr(CO)3]MeNCH2NMe2 is a stable material. The triamine Me2NCH2N(Ph)CH2NMe2 is unstable with respect to transformation to 1,3,5-triphenyltriazine, but is readily trapped as the bidentate-triamineMo(CO)4. All metal complexes were characterized by single-crystal X-ray diffraction.
Preparation of all N-coordinated zirconium amide amidinates and studies of their reactions with dioxygen and water
Lamb, Adam C.,Wang, Zheng,Cook, Tabitha M.,Sharma, Bhavna,Chen, Shu-Jian,Lu, Zheng,Steren, Carlos A.,Lin, Zhenyang,Xue, Zi-Ling
, p. 2 - 14 (2015/12/09)
Zr(NR2)2[MeC(NiPr)2]2 (R = Me, 1; Et, 2) have been prepared through aminolysis and their reactions with O2 and water have been studied. Two major products from the reactions are the oxo dimer {(μ-O)Zr[MeC(NiPr)2]2}2 (3) and its insoluble polymer {(μ-O)Zr[MeC(NiPr)2]2}n (4). Over time the dimer 3 polymerizes to 4. Zr peroxo trimer {(μ-η2:η2-O2)Zr[MeC(NiPr)2]2}3 (5) was also observed from the reaction of 1 with O2 and its crystal structure is reported. DFT calculations show that the reaction of 1 with O2 follows a radical process, yielding the peroxo trimer 5. Mass spectrometric studies of the reactions of water in air with 1 and 2 show the formation of the oxo monomer (O=)Zr[MeC(NiPr)2]2 (6), oxo dimer {(μ-O)Zr[MeC(NiPr)2]2}2 (3), and the dihydroxy monomer (HO)2Zr[MeC(NiPr)2]2 (7). In addition, the cations {Zr(NR2)[MeC(NiPr)2]2}+ (R = Me, Et) were observed. 2 revealed an interesting dynamic NMR behavior. Variableerature (VT) NMR spectroscopy has been used to study the Bailar twist process in 2, giving activation parameters ΔH? = 10.9(1.1) kcal mol-1, ΔS? = -11(4) eu and ΔG?303 K = 14(2) kcal mol-1.
Reactions of zirconium amide amidinates with dioxygen. Observation of an unusual peroxo intermediate in the formation of oxo compounds
Lamb, Adam C.,Lu, Zheng,Xue, Zi-Ling
supporting information, p. 10517 - 10520 (2014/12/10)
Reaction of d0 Zr(NMe2)2[MeC(N iPr)2]2 (1) with O2 at -30°C gives three Zr containing products: a peroxo trimer {(μ-η2: η2-O2)Zr[MeC(NiPr)2] 2}3 (2), an oxo dimer {(μ-O)Zr[MeC(N iPr)2]2}2 (3), and an oxo polymer {(μ-O)Zr[MeC(NiPr)2]2}n (4). 2 is a rarely observed peroxo complex from the reaction of a d0 complex with O2. This journal is the Partner Organisations 2014.
Synthesis and aminomethylation of 7-hydroxy-5-methoxyisoflavones
Mrug,Bondarenko,Khilya,Frasinyuk
, p. 235 - 241 (2013/07/26)
A synthetic method for 7-hydroxy-5-methoxyisoflavones starting from 5,7-dihydroxyisoflavones was developed. Dimethylcarbamoylchloride was proposed for protection of the 7-hydroxy group. Aminomethylation of the synthesized 7-hydroxy-5-methoxyisoflavones by formaldehyde aminals was studied.
Photophysical properties and OLED performance of light-emitting platinum(ii) complexes
Kourkoulos, Dimitrios,Karakus, Cüneyt,Hertel, Dirk,Alle, Ronald,Schmeding, Sebastian,Hummel, Johanna,Risch, Nikolaus,Holder, Elisabeth,Meerholz, Klaus
supporting information, p. 13612 - 13621 (2013/09/23)
The synthesis, photophysical properties and application as emitters in solution-processed multi-layer organic light-emitting diodes (OLEDs) of a series of blue-green to red light-emitting phosphorescent platinum(ii) complexes are reported. These complexes consist of phenylisoquinoline, substituted phenylpyridines or tetrahydroquinolines as C^N cyclometalating ligands and dipivaloylmethane as an ancillary ligand. Depending on both the structure of the C^N cyclometalating ligands and the dopant concentration in the matrix, these platinum(ii) complexes exhibit different aggregation tendencies. This property affects the photoluminescence spectra of the investigated compounds and colour-stability of the fabricated OLEDs. Using the blue-green to yellow-green emitting complexes, the best results were obtained with the 2-(4- trifluoromethylphenyl)-5,6,7,8-tetrahydroquinoline based platinum(ii) complex. A maximum luminous efficiency of 4.88 cd A-1 and a power efficiency of 4.65 lm W-1, respectively, were achieved. Employing the red emitting phenylisoquinoline based complex as an emitter, colour-stable and efficient (4.71 cd A-1, 5.12 lm W-1) devices were obtained.
Reactions of group 4 amide guanidinates with dioxygen or water. Studies of the formation of oxo products
Sharma, Bhavna,Callaway, Tabitha M.,Lamb, Adam C.,Steren, Carlos A.,Chen, Shu-Jian,Xue, Zi-Ling
supporting information, p. 11409 - 11421 (2013/10/22)
Reactions of the zirconium amide guanidinates (R2N) 2M[iPrNC(NR2)NiPr]2 (R = Me, M = Zr, 1; M = Hf, 2; R = Et, M = Zr, 3) with O2 or H 2O give products that are consistent with the oxo dimers {M(μ-O)[iPrNC(NR2)NiPr]2} 2 (R = Me, M = Zr, 4; M = Hf, 5; R = Et, M = Zr, 6) and polymers {M(μ-O)[iPrNC(NR2)NiPr]2} n (R = Me, M = Zr, 7; M = Hf, 8; R = Et, M = Zr, 9). Mass spectrometric (MS) analyses of the reactions of water in air with 1 and 2 show formation of the Zr monomer Zr(=O)[iPrNC(NMe2)N iPr]2 (10), oxo dimers 4 and 5, and dihydroxyl complexes M(OH)2[iPrNC(NMe2)NiPr]2 (M = Zr, 11; Hf, 12). Similar MS analyses of the reaction of diethylamide guanidinate 3 with water in air show the formation of Zr(=O)[ iPrNC(NEt2)NiPr]2 (13), Zr(OH) 2[iPrNC(NEt2)NiPr]2 (14), 6, and {(Et2N)Zr[iPrNC(NEt2)N iPr]2}+ (15). Kinetic studies of the reaction between 1 and a continuous flow of 1.0 atm of O2 at 80-105 C indicate that it follows pseudo-first-order kinetics with ΔH? = 8.7(1.1) kcal/mol, ΔS? = -54(3) eu, ΔG ?358 K = 28(2) kcal/mol, and a half-life of 213(1) min at 85 C.
Oxygen and temperature sensitivity of blue to green to yellow light-emitting Pt(ii) complexes
Karakus, Cueneyt,Fischer, Lorenz H.,Schmeding, Sebastian,Hummel, Johanna,Risch, Nikolaus,Schaeferling, Michael,Holder, Elisabeth
experimental part, p. 9623 - 9632 (2012/08/28)
The synthesis and photophysical properties of a series of yellow-green to blue-green emitting heteroleptic, cyclometalated Pt(ii)(acac) complexes based on substituted phenylpyridine and tetrahydroquinoline ligands is reported. The luminescence intensities and lifetimes of these compounds were also studied in poly(styrene) films with respect to their responses to oxygen and temperature. Particularly, due to the insensitivity to oxygen quenching, these complexes are promising candidates as inert reference dyes in optical sensors. On the other hand, the Pt(ii) complex with 2-(4-bromophenyl)-5,6,7,8-tetrahydroquinoline as C^N ligand, displays a strong temperature quenching effect. The distinct response to temperature was additionally calibrated after incorporation in poly(vinylidene chloride-co-acrylonitrile) serving as oxygen-blocking matrix copolymer. The resulting yellow-green-emitting temperature sensor signifies an interesting alternative to the available mostly red emitting temperature-sensitive probes.
Substituted Sulfonamide Compounds
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Page/Page column 36, (2009/07/25)
Substituted sulfonamide compounds corresponding to the formula I wherein m, n, p, Q, R1, R2, R3, R4, X, Y and Z have the respective meanings defined herein, pharmaceutical compositions containing such compounds, a process for their preparation, and the use of such compounds for the treatment and/or inhibition of pain and other conditions mediated by bradykinin receptor 1 (B1R) and/or bradykinin receptor 2 (B2R).
SUBSTITUTED SULFONAMIDE DERIVATIVES
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Page/Page column 109, (2009/08/16)
The invention relates to substituted sulfonamide derivatives of the general formula (I'); processes for their preparation, medicaments containing these compounds, and the use of substituted sulfonamide derivatives for the preparation of medicaments
