1236282-90-8Relevant academic research and scientific papers
Toward Pyrrolo[2,3- d ]pyrimidine scaffolds
El Kaim, Laurent,Grimaud, Laurence,Wagschal, Simon
supporting information; experimental part, p. 5343 - 5346 (2010/10/04)
(Figure presented) Herein, we present a new route to highly substituted pyrrolo[2,3-d]pyrimidines featuring a Ugi-Smiles/Sonogashira cascade followed by an efficient base-catalyzed intramolecular cyclization. When formaldehyde is chosen as input in the Ugi-Smiles step, aromatic fused systems are eventually obtained through the isomerization of an exo-alkylidene intermediate.
