123629-39-0

Upstream product

• 141-97-9 ethyl acetoacetate 
• 104-55-2 3-phenyl-propenal 
• 57-13-6 urea 
• 14371-10-9 (E)-3-phenylpropenal 

Downstream Products

• 363138-51-6 ethyl 6-methyl-2-oxo-4-(1-phenylethyl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate 

Relevant academic research and scientific papers

One-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones, thiones and 2-selenoxo DHPMs using 1-butyl-3-methylimidazolium hydrogen sulfate as non-halogenated ionic liquid

1-Butyl-3-methylimidazolium hydrogen sulfate ([BMIM][HSO4]) as a non-halogenated ionic liquid (IL) was used for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones and thiones or 2-selenoxo DHPMs in a Biginelli type multi-component reaction. By us

A one-pot Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones catalyzed by triphenylphosphine as Lewis base

We report herein the use of triphenylphosphine (TPP) as a new catalyst for the one-pot Biginelli reaction coupling of β-ketoesters, aldehydes and urea (or thiourea) to afford the corresponding dihydropyrimidinones/thiones.

Ferric chloride/tetraethyl orthosilicate as an efficient system for synthesis of dihydropyrimidinones by Biginelli reaction

An efficient method for the Biginelli reaction of aldehydes, acetoacetate esters and urea employing tetraethyl orthosilicate in the presence of ferric chloride is described. These improved reaction conditions allow the preparation of a wide variety of substituted dihydropyrimidinones (including sterically encumbered ones) in high yields and purity under mild reaction conditions.

Potassium monoperoxysulfate an efficient catalyst for Biginelli reaction under aqueous conditions

Biginelli reaction was carried out successfully in aqueous medium using potassium monoperoxysulfate as catalyst. This method can be applied for various aldehydes to get the desired product in very good yields with high purity.

Silica-supported ZnCl2 - A highly active and reusable heterogeneous catalyst for the one-pot synthesis of dihydropyrimidinones-thiones

A novel silica-supported zinc chloride catalyst was prepared and investigated for the Biginelli reaction. The key features of the catalyst include rapid reaction with 100% conversion of aldehyde, good catalyst recyclability, and high stability under the r

Microwave promoted Y(NO3)3·6H2O catalyzed Biginelli synthesis of dihydropyrimidin-2-ones

Biginelli synthesis of 3,4-dihydropyrimidinones from aldehydes, β-keto ester and urea using yttrium nitrate hexahydrate, as an efficient catalyst are demonstrated under microwave condition. This method offers significant advantages, such as high yields, s

Preparation method and application of novel ionic salicylaldehyde Schiff base zirconium complex (by machine translation)

The invention belongs to the technical field of catalytic organic synthesis, and particularly relates to a preparation method and application of a novel ionic salicylaldehyde Schiff base zirconium complex. The cationic part is formed by coordination of zi

Method for catalytically synthesizing 3, 4-dihydropyrimidine-2 (1H)-ketone in green manner

The invention discloses green catalytic Biginelli reaction, and discloses a method for synthesizing 3, 4-dihydropyrimidine-2 (1H)-ketone and derivatives thereof by the aid of 'one-pot processes'. Resin D732 is used as a catalyst, ethyl alcohol is used as a solvent, and the usage of the catalyst is 0.2g/1mmoL aldehyde. The method includes carrying out reflux reaction at the temperatures of 78 DEG Cfor 1-5 hours; filtering out the resin after the reaction is completely carried out; cooling filter liquor by the aid of ice water and then carrying out filter, ethyl alcohol re-crystallization and drying to obtain pure products. Compared with the traditional methods for synthesizing 3, 4-dihydropyrimidine-2 (1H)-ketone by the aid of acid used as a catalyst, the method has the obvious advantagesthat reaction conditions are mild, the method is high in efficiency, short in time and easy to operate, only few byproducts can be generated, and the products have good colors and are high in purity;particularly, the resin D732 used as the catalyst is low in cost, easy to prepare, store and transport and good in repeatability, is easily available and is green and environmentally friendly, accordingly, the method has an excellent industrial application prospect, and the like.

Nickel Chloride Hexahydrate Catalyzed Multicomponent Biginelli's Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones and Thiones

An efficient protocol is reported for the one-pot three-component Bignelli synthesis of a series of 3,4-dihydropyrimidine-2(1H)-ones and thiones in good yields (66–90%) from the aldehydes (4-benzyloxybenzaldehyde, 5-bromovanilin, 4-formyl-1-cyclohexene, a

Synthesis and in vitro antiviral evaluation of 4-substituted 3,4-dihydropyrimidinones

A series of 4-substituted 3,4-dihydropyrimidine-2-ones (DHPM) was synthesized, characterized by IR,1H NMR,13C NMR and HRMS spectra. The compounds were evaluated in vitro for their antiviral activity against a broad range of DNA and R