1236303-18-6

Basic information

• Product Name: C₁₉H₁₇N₃O₃
• CAS NO: 1236303-18-6
• Molecular Weight: 335.362
• Mol File: 1236303-18-6.mol

Chemical Properties

• CAS DataBase Reference: C₁₉H₁₇N₃O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₉H₁₇N₃O₃(1236303-18-6)
• EPA Substance Registry System: C₁₉H₁₇N₃O₃(1236303-18-6)

Safety Data

• Hazardous Substances Data: 1236303-18-6(Hazardous Substances Data)

Upstream product

• 62-53-3 aniline 
• 1236303-23-3 C₁₁H₁₂N₂O₄ 
• 1236303-37-9 8-ethyl-4-methoxy-N-phenyl-5H-pyrano[4,3-d]pyrimidine-2-carboxamide 
• 1236303-21-1 methyl 8-ethyl-4-methoxy-5H-pyrano[4,3-d]pyrimidine-2-carboxylate 
• 1236303-35-7 8-ethyl-4-methoxy-5H-pyrano[4,3-d]pyrimidine-2-carboxylic acid 
• 1236303-34-6 C₁₆H₁₅N₃O₃ 
• 106-96-7 propargyl bromide 
• 1236303-33-5 C₁₀H₁₀N₂O₄ 
• 848891-83-8 2-chloro-8-ethyl-4-methoxy-5H-pyrano[4,3-d]pyrimidine 

Relevant articles and documents

Efficient total synthesis of (S)-14-azacamptothecin

An efficient total synthesis of (S)-14-azacamptothecin has been accomplished in 10 steps and 56% overall yield from 5H-pyrano[4, 3-d]pyrimidine 8.A mild Hendrickson reagent-triggered intramolecular cascade cyclization, a highly enantioselective dihydroxylation, and an efficient palladium-catalyzed transformation of an O-allyl into N-allyl group are the key steps in the synthesis. This work provides a much higher overall yield than the previous achievement and shows sound flexibility for the further applications that will lead to new bioactive analogues.