1236312-48-3

Upstream product

• 331-39-5 caffeic acid 
• 951288-55-4 (E)-benzyl 3-(3,4-bis(benzyloxy)phenyl)acrylate 
• 54429-62-8 (E)-3-(3,4-bis(benzyloxy)phenyl)acrylic acid 
• 362632-36-8 C₂₃H₂₄O₅ 

Downstream Products

• 20728-73-8 5,7,3',4'-tetra-O-benzyl-(+)-catechin 
• 154-23-4 catechin 

Relevant academic research and scientific papers

Synthesis method of procyanidine compound Catechin

The invention relates to a synthesis method of a procyanidine compound Catechin and belongs to the field of chemical synthesis. The method is as below: conducting benzyl protection reaction on trans-caffeic acid to produce O-Bz caffeic acid; subjecting O-Bz caffeic acid to an ester reduction reaction for synthesis of allyl alcohol; subjecting allyl alcohol to a Sharpless dihydroxylation reaction to synthesize a trihydroxy compound; subjecting the trihydroxy compound to a selective sulfonylation reaction to synthesize sulfonate; subjecting the sulfonate to an O-Ts leaving reaction to synthesize ternary epoxy; conducting a hydroxy mitsunobu reaction to synthesiz O-Ph epoxy; subjecting O-Ph epoxy to a ring-forming reaction to synthesize O-Bz Catechi; subjecting O-Bz Catechin to a palladium carbon deprotection reaction to synthesize the procyanidine compound Catechin (shown in figure). The invention has the characteristics of few reaction steps, high total yield, good product selectivity, and suitability for industrial production.