1236352-67-2Relevant academic research and scientific papers
Metal-free synthesis of polysubstituted pyrroles by (diacetoxyiodo)benzene- mediated cascade reaction of 3-alkynyl amines
Mo, Dong-Liang,Ding, Chang-Hua,Dai, Li-Xin,Hou, Xue-Long
, p. 3200 - 3204 (2013/01/12)
Free metal jacket: A regioselective metal-free synthesis of polysubstituted pyrroles has been developed through a (diacetoxyiodo)benzene-mediated cascade reaction of alkynyl amines in moderate to good yield (see scheme).
Inter- and intramolecular hydroamination with a uranium dialkyl precursor
Broderick, Erin M.,Gutzwiller, Nathaniel P.,Diaconescu, Paula L.
experimental part, p. 3242 - 3251 (2010/09/06)
The same uranium dibenzyl complex supported by a ferrocene-diamide ligand was used as a precatalyst for both inter-and intramolecular hydroamination reactions. Mechanistic and reactivity studies were undertaken to determine whether the two types of reactions follow the same pathway. The experimental results indicate that more than one mechanism may be operating and that the change in mechanism may be dependent on the type of reaction (inter-versus intramolecular) and/or the type of substrate (primary versus secondary amine). In addition, the synthesis and characterization of a bridging-imide diuranium(IV) complex and of benzyl-and anilide-aryloxide uranium(IV) complexes are reported, and their role in hydroamination reactions is discussed.
Gold-catalyzed synthesis of α-fluoro acetals and α-fluoro ketones from alkynes
De Haro, Teresa,Nevado, Cristina
supporting information; experimental part, p. 2767 - 2772 (2010/12/25)
A new method to synthesize α-fluoro acetals and α-fluoro ketones is presented here. In the presence of alcohols and Selectfluor, catalytic amounts of gold selectively transformed alkynes into the corresponding fluorinated acetals or ketones depending on the reaction conditions. This protocol has been applied to both terminal and internal alkynes showing a high degree of chemo- and regioselectivity. The reaction mechanism seems to proceed via two co-existing pathways, since at least partially, the formation of the C(sp3)-F bond in the final products occurs at the metal center.
