1236360-20-5Relevant academic research and scientific papers
Blocking oestradiol synthesis pathways with potent and selective coumarin derivatives
Niinivehmas, Sanna,Postila, Pekka A.,Rauham?ki, Sanna,Manivannan, Elangovan,Kortet, Sami,Ahinko, Mira,Huuskonen, Pasi,Nyberg, Niina,Koskimies, Pasi,L?tti, Sakari,Multam?ki, Elina,Juvonen, Risto O.,Raunio, Hannu,Pasanen, Markku,Huuskonen, Juhani,Pentik?inen, Olli T.
, p. 743 - 754 (2018)
A comprehensive set of 3-phenylcoumarin analogues with polar substituents was synthesised for blocking oestradiol synthesis by 17-β-hydroxysteroid dehydrogenase 1 (HSD1) in the latter part of the sulphatase pathway. Five analogues produced ≥62% HSD1 inhib
Development of new Coumarin-based profluorescent substrates for human cytochrome P450 enzymes
Juvonen, Risto O.,Ahinko, Mira,Huuskonen, Juhani,Raunio, Hannu,Pentik?inen, Olli T.
, p. 1015 - 1024 (2018/12/11)
Cytochrome P450 (CYP) enzymes constitute an essential xenobiotic metabolizing system that regulates the elimination of lipophilic compounds from the body. Convenient and affordable assays for CYP enzymes are important for assessing these metabolic pathway
Monoamine oxidase (MAO) inhibitory activity: 3-phenylcoumarins versus 4-hydroxy-3-phenylcoumarins
Delogu, Giovanna L.,Serra, Silvia,Quezada, Elias,Uriarte, Eugenio,Vilar, Santiago,Tatonetti, Nicholas P.,Vi?a, Dolores
, p. 1672 - 1676 (2014/08/18)
Monoamine oxidase (MAO) is a useful target in the treatment of neurodegenerative diseases and depressive disorders. Both isoforms, MAO-A and MAO-B, are known to play critical roles in disease progression, and as such, the identification of novel, potent a
