1236384-02-3

Basic information

• Product Name: (S)-3-chloro-2-hydroxypropyl dibenzylamine
• Synonyms: (S)-3-chloro-2-hydroxypropyl dibenzylamine
• CAS NO: 1236384-02-3
• Molecular Weight: 289.805
• Mol File: 1236384-02-3.mol

Chemical Properties

• CAS DataBase Reference: (S)-3-chloro-2-hydroxypropyl dibenzylamine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-chloro-2-hydroxypropyl dibenzylamine(1236384-02-3)
• EPA Substance Registry System: (S)-3-chloro-2-hydroxypropyl dibenzylamine(1236384-02-3)

Safety Data

• Hazardous Substances Data: 1236384-02-3(Hazardous Substances Data)

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 103-49-1 dibenzylamine 

Downstream Products

• 1372665-04-7 4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 1433722-27-0 (R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide 
• 1433722-21-4 (R)-5-((dibenzylamino)methyl)dihydrofuran-2(3H)-one 
• 1411775-00-2 4-(4-{[(2R)-3-(dibenzylamino)-2-hydroxypropyl]amino}phenyl)morpholin-3-one 
• 565176-84-3 (S)-N,N-dibenzylamino-1-(oxiran-2-ylmethyl)methylamine 
• 1429334-13-3 (S)-2-(dibenzylamino)-1-(chloromethyl)ethyl acetate 
• 565176-85-4 (S)-5-((dibenzylamino)methyl)-3-(3-fluoro-4-morpholino phenyl)-isooxazol-2-one 

Relevant articles and documents

Dehydrative Annulation Strategy for the Construction of Octahydroindolizine Framework: A Diastereoselective Synthesis of (6 R,8a S)-Octahydroindolizin-6-ol

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A the advantage cuts down Sha Ban method for the preparation of intermediates thereof, and intermediate compound

The present invention discloses a preparation method for a rivaroxaban intermediate compound represented by a formula 5, wherein the preparation method comprises the following steps: carrying out a benzyl group removing reaction of a compound 4 in a solvent to prepare a compound 5. The present invention further discloses a rivaroxaban preparation method and intermediate compounds. According to the preparation method, chiral raw materials are easy to obtain, and have cheap price, the process is simple, the post treatment is simple, the intermediate and the final product are easy to purify, the total yield is high, the purity is high, and industrial production is easily achieved.

PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF

TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF

A method for preparing the linezolid (compound 1), which comprises the steps of: (1) carrying out the debenzyl reaction of compound 4 in solvent, to obtain the compound 5 or its acetate; (2) carrying out the acetylation reaction in the amino of the compound 5 or its acetate obtained in step (1) in solvent to obtain the compound 1. The intermediates to prepare the compound 1 and the acetate of compound 5. The present preparation method is easy to obtain the chiral materials and the chiral materials are cheap, the process and the post treatment are simple, the intermediate products and the end product are easy to be purified, the total yield is high, their purities are also high, this preparation method is easy to be used in the industry manufacture.

METHOD FOR PREPARING LINEZOLID AND INTERMEDIATES THEREOF

A method for preparing the linezolid (compound 1), which comprises the steps of: (1) carrying out the debenzyl reaction of compound 4 in solvent, to obtain the compound 5 or its acetate; (2) carrying out the acetylation reaction in the amino of the compound 5 or its acetate obtained in step (1) in solvent to obtain the compound 1. The intermediates to prepare the compound 1 and the acetate of compound 5. The present preparation method is easy to obtain the chiral materials and the chiral materials are cheap, the process and the post treatment are simple, the intermediate products and the end product are easy to be purified, the total yield is high, their purities are also high, this preparation method is easy to be used in the industry manufacture.