565176-84-3

Upstream product

• 67843-74-7 (S)-epichlorohydrin 
• 103-49-1 dibenzylamine 
• 1236384-02-3 (S)-3-chloro-2-hydroxypropyl dibenzylamine 

Downstream Products

• 1433722-21-4 (R)-5-((dibenzylamino)methyl)dihydrofuran-2(3H)-one 
• 1433722-27-0 (R)-5-(dibenzylamino)-4-hydroxy-N-methoxy-N-methyl pentanamide 
• 1433722-31-6 (R)-8-(dibenzylamino)-7-hydroxyoctan-4-one 
• 1433722-35-0 (R)-7-((tert-butyldimethylsilyl)oxy)-8-(dibenzylamino)octan-4-one 
• 565176-85-4 (S)-5-((dibenzylamino)methyl)-3-(3-fluoro-4-morpholino phenyl)-isooxazol-2-one 
• 1372665-04-7 4-{4-[(5S)-5-((dibenzylamino)methyl)-2-oxo-1,3-oxazolidin-3-yl]phenyl}morpholin-3-one 
• 1411775-00-2 4-(4-{[(2R)-3-(dibenzylamino)-2-hydroxypropyl]amino}phenyl)morpholin-3-one 

Relevant academic research and scientific papers

Controlled/living ring-opening polymerization of glycidylamine derivatives using t -Bu-P4/alcohol initiating system leading to polyethers with pendant primary, secondary, and tertiary amino groups

The combination of t-Bu-P4 and alcohol was found to be an excellent catalytic system for the controlled/living ring-opening polymerization (ROP) of N,N-disubstituted glycidylamine derivatives, such as N,N-dibenzylglycidylamine (DBGA), N-benzyl-N-methylglycidylamine, N-glycidylmorpholine, and N,N-bis(2-methoxyethyl)glycidylamine, to give well-defined polyethers having various pendant tertiary amino groups with predictable molecular weights and narrow molecular weight distributions (typically Mw/Mn 4-catalyzed ROP of these monomers in toluene at room temperature proceeded in a living manner, which was confirmed by a MALDI-TOF MS analysis, kinetic measurement, and postpolymerization experiment. The well-controlled nature of the present system enabled the production of the block copolymers composed of the glycidylamine monomers. The polyethers having pendant primary and secondary amino groups, i.e., poly(glycidylamine) and poly(glycidylmethylamine), respectively, were readily obtained by the debenzylation of poly(DBGA) and poly(BMGA), respectively, through the treatment with Pd/C in THF/MeOH under a hydrogen atmosphere. To the best of our knowledge, this report is the first example of the controlled/living polymerization of glycidylamine derivatives, providing a rapid and comprehensive access to the polyethers having primary, secondary, and tertiary amino groups.

A preparation method of the pregabalin

The invention discloses a method for preparation of pregabalin. In particular, this invention refers to R - 1 - (dibenzyl amino) - 4 - methyl - 2 - chloro-pentane (compound IV) as raw materials for preparing pregabalin (compound I). The invention has a starting raw materials are easy, less reaction steps and the like.

A the advantage cuts down Sha Ban method for the preparation of intermediates thereof, and intermediate compound

The present invention discloses a preparation method for a rivaroxaban intermediate compound represented by a formula 5, wherein the preparation method comprises the following steps: carrying out a benzyl group removing reaction of a compound 4 in a solvent to prepare a compound 5. The present invention further discloses a rivaroxaban preparation method and intermediate compounds. According to the preparation method, chiral raw materials are easy to obtain, and have cheap price, the process is simple, the post treatment is simple, the intermediate and the final product are easy to purify, the total yield is high, the purity is high, and industrial production is easily achieved.

Dehydrative Annulation Strategy for the Construction of Octahydroindolizine Framework: A Diastereoselective Synthesis of (6 R,8a S)-Octahydroindolizin-6-ol

A dehydrative annulation strategy involving an intramolecular ring closure under a Mitsunobu-Type reaction condition has been used for the construction of octahydroindolizine framework successfully. This strategy that was reported to be unsuccessful when

PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF

TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.

Diastereoselective total synthesis of 3,6-disubstituted piperidine alkaloids, (3R,6S)-epi-pseudoconhydrine and (3R,6R)-pseudoconhydrine in memory of Dr. K. Anji Reddy, the founder of Dr. Reddy's Laboratories Ltd.

Diastereoselective total synthesis of 3,6-disubstituted piperidine alkaloids, epi-pseudoconhydrine (1) and pseudoconhydrine (2) has been developed starting from enantiopure (S)-epichlorohydrin. The key steps in the synthesis of these alkaloids involved α-aminobutyrolactone ring opening with N,O-dimethyhydroxyl amine followed by a Grignard reaction and cascade debenzylation-reductive aminative cyclization under hydrogenation conditions. High de was obtained in the synthesis of epi-pseudoconhydrine (1).

PROCESS FOR THE PREPARATION OF A RIVAROXABAN AND INTERMEDIATES FORMED IN SAID PROCESS

The invention relates to a process for the preparation of 5-chloro- N- ({(5-S)-2-oxo3-[4-(3-oxo-morj)holine-4-yl)-phenyl]-l,3-oxazolidine-5-yl}-methyl) thiophen-2-carboxamide having the INN rivaroxaban. The process is characterized by the reactions according to claim 1. The invention also relates to intermediates formed in the above process.