565176-84-3Relevant articles and documents
Controlled/living ring-opening polymerization of glycidylamine derivatives using t -Bu-P4/alcohol initiating system leading to polyethers with pendant primary, secondary, and tertiary amino groups
Isono, Takuya,Asai, Shunsuke,Satoh, Yusuke,Takaoka, Toshimitsu,Tajima, Kenji,Kakuchi, Toyoji,Satoh, Toshifumi
, p. 3217 - 3229 (2015)
The combination of t-Bu-P4 and alcohol was found to be an excellent catalytic system for the controlled/living ring-opening polymerization (ROP) of N,N-disubstituted glycidylamine derivatives, such as N,N-dibenzylglycidylamine (DBGA), N-benzyl-N-methylglycidylamine, N-glycidylmorpholine, and N,N-bis(2-methoxyethyl)glycidylamine, to give well-defined polyethers having various pendant tertiary amino groups with predictable molecular weights and narrow molecular weight distributions (typically Mw/Mn 4-catalyzed ROP of these monomers in toluene at room temperature proceeded in a living manner, which was confirmed by a MALDI-TOF MS analysis, kinetic measurement, and postpolymerization experiment. The well-controlled nature of the present system enabled the production of the block copolymers composed of the glycidylamine monomers. The polyethers having pendant primary and secondary amino groups, i.e., poly(glycidylamine) and poly(glycidylmethylamine), respectively, were readily obtained by the debenzylation of poly(DBGA) and poly(BMGA), respectively, through the treatment with Pd/C in THF/MeOH under a hydrogen atmosphere. To the best of our knowledge, this report is the first example of the controlled/living polymerization of glycidylamine derivatives, providing a rapid and comprehensive access to the polyethers having primary, secondary, and tertiary amino groups.
A the advantage cuts down Sha Ban method for the preparation of intermediates thereof, and intermediate compound
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Paragraph 0111-0114; 0116; 0119; 0170, (2016/10/09)
The present invention discloses a preparation method for a rivaroxaban intermediate compound represented by a formula 5, wherein the preparation method comprises the following steps: carrying out a benzyl group removing reaction of a compound 4 in a solvent to prepare a compound 5. The present invention further discloses a rivaroxaban preparation method and intermediate compounds. According to the preparation method, chiral raw materials are easy to obtain, and have cheap price, the process is simple, the post treatment is simple, the intermediate and the final product are easy to purify, the total yield is high, the purity is high, and industrial production is easily achieved.
PROCESSES FOR THE PREPARATION OF 5-CHLORO-N-({(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL) PHENYL]-1,3-OXAZOLIDIN-5-YL}METHYL)-2-THIOPHENE-CARBOXAMIDE AND INTERMEDIATES THEREOF
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Page/Page column 80, (2013/04/13)
TThe present invention provides processes for the preparation of 5-chloro-N-({(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-1,3-oxazolidin-5-yl}methyl)-2-thiophene-carboxamide (I) and intermediates thereof. Also provides novel intermediates and their use in the synthesis of oxazolidine derivatives.