1236397-66-2Relevant academic research and scientific papers
Discovery of tetrahydro-β-carbolines as inhibitors of the mitotic kinesin KSP
Liu, Fei,Yu, Li-Qin,Jiang, Cheng,Yang, Lei,Wu, Wu-Tong,You, Qi-Dong
experimental part, p. 4167 - 4177 (2010/09/12)
Inhibitors of kinesin spindle protein (KSP) are a promising class of anticancer agents that cause mitotic arrest in cells from a failure to form functional bipolar mitotic spindles. Here, we report the synthesis and biological evaluation of a novel series of tetrahydro-β-carboline analogs based on the structure of the known KSP inhibitor HR22C16. Preferred compounds 11b, 12a and 19b were identified as potent inhibitors in a KSP ATPase assay with good anti-proliferative activity in A549 cells.
