1236397-58-2Relevant academic research and scientific papers
Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein
Bach, Jordan,DiBernardo, Celine,Durham, Sierra,Eagon, Scott,Everson, Nikalet,Falade, Mofolusho O.,Hammill, Jared T.,Kimball, Joshua J.,Kiplin Guy, R.,Lazaro, Horacio,Pillai, Dylan R.,Rice, Amy L.,Sisley, Tyler A.,Walls, Michael J.
, (2020)
A series of tetrahydro-β-carboline derivatives of a lead compound known to target the heat shock 90 protein of Plasmodium falciparum were synthesized and assayed for both potency against the parasite and toxicity against a human cell line. Using a rationa
Discovery of tetrahydro-β-carbolines as inhibitors of the mitotic kinesin KSP
Liu, Fei,Yu, Li-Qin,Jiang, Cheng,Yang, Lei,Wu, Wu-Tong,You, Qi-Dong
experimental part, p. 4167 - 4177 (2010/09/12)
Inhibitors of kinesin spindle protein (KSP) are a promising class of anticancer agents that cause mitotic arrest in cells from a failure to form functional bipolar mitotic spindles. Here, we report the synthesis and biological evaluation of a novel series of tetrahydro-β-carboline analogs based on the structure of the known KSP inhibitor HR22C16. Preferred compounds 11b, 12a and 19b were identified as potent inhibitors in a KSP ATPase assay with good anti-proliferative activity in A549 cells.
