123646-95-7Relevant articles and documents
Synthesis of cyclic guanidine intermediates of anatoxin-a(s) in both racemic and enantiomerically pure forms
Moura, Sidnei,Pinto, Ernani
, p. 967 - 969 (2010)
The alkyl chain of anatoxin-a(s) (cyclic guanidines), which can be used as an intermediate in the total synthesis of anatoxin-a(s), was synthesized in both racemic and enantiomerically pure forms. These enantiomerically pure cyclic compounds can be used as chiral inductors in some reactions. The two racemic routes disclosed herein have the advantages of high overall yield and mild reaction conditions. Both routes proceed through an intermediate 2,3-diaminoacid - an important synthetic scaffold - with good yields. Furthermore, the N,N-dimethyl-2(tosylimino)imidazolidine-4-carboxamide might be obtained from 2-(tosylimino)imidazolidine-4-carboxylic acid followed by selective reduction of the carbonyl functionality. All synthesized compounds were analyzed by mass spectrometry and 1H NMR and 1C NMR spectroscopy. Georg Thieme Verlag Stuttgart - New York.
