123646-99-1

Upstream product

• 873-75-6 4-bromobenzenemethanol 
• 57-13-6 urea 
• 123-54-6 acetylacetone 
• 1122-91-4 4-bromo-benzaldehyde 

Downstream Products

• 1194097-20-5 5-acetyl-4-(4'-bromophenyl)-6-methylpyrimidin-2(1H)-one 
• 1445609-71-1 5-acetyl-4-(4-bromophenyl)-6-(dichloromethyl)-3,4-dihydropyrimidin-2(1H)-one 
• 1263324-34-0 4-(4-bromophenyl)-5-chloro-1,2-dihydro-2-oxoquinazoline-3(4H)-carbaldehyde 
• 1263324-30-6 4-(4-bromophenyl)-5-chloro-1,2-dihydro-2-oxoquinazoline-3,8(4H)-dicarbaldehyde 

Relevant academic research and scientific papers

Solvent-Free Ball-Milling Biginelli Reaction by Subcomponent Synthesis

We report here an understanding of systems chemistry on small molecules through covalent mechanochemistry. As a proof-of-concept, the multicomponent Biginelli reaction by subcomponent synthesis was considered as a model system. Reactions were performed un

Synthesis method of dihydropyrimidinone compound

The invention discloses a synthesis method of a dihydropyrimidone compound, which belongs to the technical field of organic synthesis, and comprises the following steps: by taking benzaldehyde or a derivative thereof, ethyl acetoacetate or acetylacetone a

Air-stable zirconium (IV)-salophen perfluorooctanesulfonate as a highly efficient and reusable catalyst for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones under solvent-free conditions

An air-stable complex of zirconium (IV)-salophen perfluorooctanesulfonate (1) was successfully synthesized by reacting Zr (salphen)Cl2 and C8F17SO3Ag. Complex 1 was characterized and studied by different techniq

Exploiting silver trifluoromethanesulfonate as efficient and reusable catalyst for the synthesis of dihydropyrimidine derivatives under different reaction environments

Different results were generated under different reaction conditions for the multicomponent reactions. Herein, an efficiently improved and mild protocol for the synthesis of dihydropyrimidine derivatives using cheap silver trifluoromethanesulfonate (CFsu

BiVO4-NPs: an efficient nano-catalyst for the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives

BiVO4-NPs can be used as an efficient and reusable nano-catalyst for the promotion of the synthesis of biscoumarins, bis(indolyl)methanes and 3,4-dihydropyrimidin-2(1H)-ones (thiones) derivatives. The structures of the products were characteriz

Polyaniline Supported FeCl3: An Effective Heterogeneous Catalyst for Biginelli Reaction

Abstract: Polyaniline supported FeCl3 is prepared and tested as an efficient heterogeneous Lewis acidic catalyst for the Biginelli reaction. The catalyst PANI–FeCl3 shows excellent activity in the synthesis of dihydropyrimidinones fr

Air-stable Organobismuth(V) Bisperfluorooctanesulfonate as an Efficient Catalyst for the Synthesis of N-Containing Compounds

Triphenyl bismuth bisperfluorooctanesulfonate is an air- and water-stable Lewis acid. It exhibits high catalytic efficiency for the synthesis of nitrogen heterocycles such as diindolylmethane derivatives, dihydropyrimidinones, dihydropyridines and 1,2-disubstitued benzimidazoles under mild condition. Furthermore, it can be reused without loss of activity in a test of five cycles.This catalytic system affords a simple and efficient way for the synthesis of N-containing compounds.

Air-stable zirconocene bis(perfluorobutanesulfonate) as a highly efficient catalyst for synthesis of N-heterocyclic compounds

Zirconocene bis(perfluorobutanesulfonate) is air- and water-stable and proved to be ionic on basis of conductivity measurements. It exhibits high catalytic efficiency for the synthesis of N-heterocyclic compounds under solvent-free condition, such as benzimidazoles, benzodiazepines, dihydropyrimidinones and dihydropyridines under mild condition. Furthermore, it can be reused without loss of activity in a test of five cycles. This catalytic system affords a simple and efficient approach for the synthesis of N-heterocyclic compounds.

N-Sulfonic acid poly(4-vinylpyridinium) chloride as a highly efficient and reusable catalyst for the Biginelli reaction

A mild, simple and efficient procedure for the preparation of 3,4-dihydropyrimidin-2(1H)-ones and -thiones is described using N-sulfonic acid poly(4-vinylpyridinium) chloride (NSPVPC) as a heterogeneous and efficient catalyst under solvent-free conditions

Regioselective chlorination at C-6 methyl position of 3,4-dihydropyrimidin- 2(1H)-ones using (dichloroiodo)benzene

The reaction of (dichloroiodo)benzene with 4-aryl-1,2,3,4-tetrahydro-6- methyl-2-oxopyrimidine-5-carboxylates and 5-acetyl-4-aryl-3,4-dihydro-6- methylpyrimidin-2(1H)-ones resulted in geminal dichlorination at the C-6 methyl position of 3,4-dihydropyrimid