1236887-99-2

Upstream product

• 23456-78-2 1,4,5,6-tetrahydro-7H-indol-7-one 
• 824-94-2 p-methoxybenzyl chloride 

Downstream Products

• 1262892-91-0 6-[(dimethylamino)methylene]-1-(4-methoxybenzyl)-1,4,5,6-tetrahydro-7H-indole-7-one 
• 1314094-09-1 2-amine-9-(4-methoxybenzyl)-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline 
• 1314093-98-5 2-anilino-9-(4-methoxybenzyl)-6,9-dihydro-5H-pyrrolo[3,2-h]quinazoline 
• 1429642-07-8 C₁₇H₁₆N₂O₂ 

Relevant academic research and scientific papers

PHOTOCHEMOTHERAPEUTIC HETEROCYCLIC AGENTS HAVING ANTIPROLIFERATIVE AND ANTINEOPLASTIC ACTIVITY

The present invention concerns the synthesis of new analogs of angelicins, pyrrolo [3,2-h]quinoline, for the treatment of pathologies having hyperproliferative character included those having neoplastic nature. The treatment is based on the combined actio

Synthesis of pyrrolo[3,2-h]quinolinones with good photochemotherapeutic activity and no DNA damage

In the search for new photochemotherapeutic agents, a series of derivatives of the ring system pyrrolo[3,2-h]quinoline - bioisosters of the angular furocoumarin angelicin - were synthesized through a four-step synthetic approach, in reasonable overall yields. Eight of the synthesized derivatives showed a remarkable phototoxicity against a panel of four human tumor cell lines and a great dose UV-A dependence, reaching IC50 values at submicromolar level. The mode of cellular death photoinduced by pyrrolo[3,2-h]quinolines was evaluated through a series of flow cytometric analysis and other tests were performed to clarify their mechanism of action.