123703-22-0

Upstream product

• 66217-87-6 (E)-N-(1-methyl-2-phenethenyl)morpholine 
• 25236-39-9 2-phenyl-1-nitroprop-1-ene 
• 673-32-5 1-Phenylprop-1-yne 
• 30085-70-2 [E]-1-morpholino-1-phenyl-1-propene 
• 126890-14-0 <4S^*-(4α, 5β, 6α, or 6β)>-5,6-dihydro-3,5-diphenyl-6-(4-morpholinyl)-4H-1,2-oxazine N-oxide 
• 123703-16-2 <4R*-(4α,5β)>-5,6-dihydro-4,6-diphenyl-5-methyl-6-(4-morpholinyl)-4H-1,2-oxazine N-oxide 
• 5153-67-3 nitrostyrene 

Relevant academic research and scientific papers

Nickel-Catalyzed Reductive [2+2] Cycloaddition of Alkynes

The nickel-catalyzed synthesis of tetrasubstituted cyclobutenes from alkynes is reported. This transformation is uniquely promoted by the use of a primary aminophosphine, an unusual ligand in nickel catalysis. Mechanistic insights for this new transformation are provided, and postreaction modifications of the cyclobutene products to stereodefined cyclic and acyclic compounds are reported, including the synthesis of epi-truxillic acid.

CARBO- AND HETEROCYCLIZATION REACTIONS OF 2-(4-MORPHOLINYL)-1-PHENYLPROPENE AND NITROOLEFINS

The title enamine may exist in two double bond isomers.Both forms react with the nitroolefins under different conditions to afford, after hydrolysis, regioisomeric γ-nitroketones. γ-Dicarbonyl compounds are isolated from the hydrolysis at pH 2 of the 1,2-oxazine N-oxide systems, which in some cases have also been separated.

HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF CYCLIC NITRONIC ESTERS FROM 1-(4-MORPHOLINYL)-1-PHENYLPROPENE WITH NITROOLEFINS

1,2-Oxazine N-oxide derivatives could be obtained as pure isomers from the title reagents.In methanol, they opened into the corresponding Michael-type adducts, as single double bond diastereoisomers.Hydrolyses of both the systems were also highly diastereoselective, leading to γ-diketones in the former case and to γ-nitroketones in the latter.