66217-87-6

Upstream product

• 110-91-8 morpholine 
• 673-32-5 1-Phenylprop-1-yne 

Downstream Products

• 69373-32-6 (3R^*,4R^*)-3,4-diphenyl-2,5-hexanedione 
• 126890-10-6 <2R^*-(3R, 4R or 4S, 1R or 1S)>-1,4-dimethyl-2,3-diphenyl-1-(4-morpholinyl)-4-nitro-cyclobutane 
• 126890-09-3 <4R^*-(4α, 5β, 6α, or 6β)>-5,6-dihydro-3,6-dimethyl-4,5-diphenyl-6-(4-morpholinyl)-4H-1,2-oxazine N-oxide 
• 126890-22-0 <6aR^*-(6aα,7α,8α, or 8β)>-3,4,5,6,7,8-hexahydro-6aH-8-methyl-8-(4-morpholinyl)-7-phenyl-benzo-1,2-oxazine N-oxide 
• 126890-19-5 <5aS^*-(5aα,6α,7α, or 7β)>-3,4,5,5a,6,7-hexahydro-7-methyl-7-(4-morpholinyl)-6-phenyl-cyclopenta-1,2-oxazine N-oxide 
• 126890-14-0 <4S^*-(4α, 5β, 6α, or 6β)>-5,6-dihydro-3,5-diphenyl-6-(4-morpholinyl)-4H-1,2-oxazine N-oxide 
• 72652-52-9 (1R^*,1'S^*)-1-(2'-oxocyclopentyl)-1-phenyl-2-propanone 
• 94453-40-4 (1R^*,2S^*)-1-(2-oxo-cyclohexyl)-1-phenyl-2-propanone 
• 126890-20-8 (1R^*,1'S^*,2'R^* or 2'S^*)-1-(2'-nitrocyclopentyl)-1-phenyl-2-propanone 
• 126890-25-3 (1R^*,1'S^*,2'R^* or 2'S^*)-1-(2'-nitrocyclohexyl)-1-phenyl-2-propanone 
• 126890-16-2 (3R^*,4S^*,5R^* or 5S^*)-3,5-diphenyl-4-methyl-5-nitro-2-pentanone 
• 123703-22-0 (2R^*,3R^*)-1,3-diphenyl-2-methyl-1,4-pentanedione 
• 332048-20-1 [(OC)5WC(OC₂H₅)C(C(CH₃)N(C₂H₄)2O)C(C₆H₅)CHC₆H₅] 

Relevant academic research and scientific papers

Broadening the scope of group 4 hydroamination catalysis using a tethered ureate ligand

(Chemical Equation Presented) A broadly applicable group-4-based precatalyst for the hydroamination of primary and secondary amines was developed. Screening experiments involving a series of amide and urea proligands led to the discovery of a tethered bis(ureate) zirconium complex with unprecedented reactivity in the intermolecular hydroamination of alkynes and the intramolecular hydroamination of alkenes. This catalyst system is effective with primary and secondary amines, 1,2-disubstituted alkenes, and heteroatom-containing functional groups, including ethers, silanes, amines, and heteroaromatics. The gem-disubstituent effect is not required for cyclization. The catalyst is generally regioselective for the anti-Markovnikov product of intermolecular alkyne hydroamination, and chemoselective for hydroamination over C-alkylation when forming 6- and 7-membered rings from aminoalkenes.