123730-03-0Relevant articles and documents
An expeditious microwave assisted one-pot sequential route to pyrido fused imidazo[4,5-c] quinolines in green media
Rao, Ramdas Nishanth,Chanda, Kaushik
, p. 3280 - 3289 (2021/02/26)
An expeditious microwave assisted one-pot sequential route to synthesize pyrido fused imidazo[4,5-c]quinolinesviathe Pictet-Spengler cyclization strategy has been developed. In this study, substituted 2-amino pyridines are condensed with 2-bromo-2′-nitroa
Synthesis of biologically active pyridoimidazole/imidazobenzothiazole annulated polyheterocycles using cyanuric chloride in water
Pandey, Anand Kumar,Sharma, Rashmi,Singh, Awantika,Shukla, Sanjeev,Srivastava, Kumkum,Puri, Sunil K.,Kumar, Brijesh,Chauhan, Prem M. S.
, p. 26757 - 26770 (2014/07/21)
An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in an aqueous reaction medium has been developed. The protocol was successfully applied to a wide range of compounds including aryl/heteroaryl aldehydes (8a-o), ketones (10a-e), an electron-rich metallocene aldehyde (8e) and indoline-2,3-diones (12a-c) using cyanuric chloride (15-20 mol%) with tetra-n-butylammonium bromide (TBAB) (2.0 eq.) as an additive at 80-90 °C to give a good to excellent yield (66-92%) of polyheterocycles. Some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine-sensitive (CQ-S) 3D7 and chloroquine-resistant (CQ-R) K1 strains of Plasmodium falciparum. This journal is the Partner Organisations 2014.