1621431-76-2

Upstream product

• 552-89-6 2-nitro-benzaldehyde 
• 123730-03-0 7-methyl-2-(2'-nitrophenyl)imidazo<1,2-a>pyridine 
• 253684-24-1 1-(2,2-dibromovinyl)-2-nitrobenzene 
• 695-34-1 2-Amino-4-methylpyridine 
• 1621432-61-8 2-(3-methylimidazo[2,1-b]-benzothiazol-6-yl)phenylamine 

Relevant academic research and scientific papers

Synthesis of biologically active pyridoimidazole/imidazobenzothiazole annulated polyheterocycles using cyanuric chloride in water

An efficient and mild protocol for rapid access to N-fused polyheterocycles via Pictet-Spengler type 6-endo cyclization using cyanuric chloride in an aqueous reaction medium has been developed. The protocol was successfully applied to a wide range of compounds including aryl/heteroaryl aldehydes (8a-o), ketones (10a-e), an electron-rich metallocene aldehyde (8e) and indoline-2,3-diones (12a-c) using cyanuric chloride (15-20 mol%) with tetra-n-butylammonium bromide (TBAB) (2.0 eq.) as an additive at 80-90 °C to give a good to excellent yield (66-92%) of polyheterocycles. Some of the synthesized compounds were found to exhibit antiplasmodial activity against chloroquine-sensitive (CQ-S) 3D7 and chloroquine-resistant (CQ-R) K1 strains of Plasmodium falciparum. This journal is the Partner Organisations 2014.