123736-84-5Relevant academic research and scientific papers
7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
-
, (2008/06/13)
This invention relates to novel 7-acylamino-3-vinyl-cephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, of high antimicrobial activity.
7-Acylamino-3-vinylcephalosporanic acid derivatives and processes for the preparation thereof
-
, (2008/06/13)
The invention relates to novel 7-acylamino-3-vinylcephalosporanic acid derivatives of antimicrobial activity, and to methods of preparation thereof from novel intermediate compounds of the formula: STR1 in which RC is amino or a group of the formula: STR2 wherein R8 is aryl, A12 is lower alkylene having a group of the formula: =N?OR4, wherein R4 is hydrogen, cyclo(lower) alkenyl, lower alkynyl, lower alkenyl, lower alkenyl substituted by carboxy or a protected carboxy group, lower alkyl, or lower alkyl substituted by one or more substituent(s) selected from carboxy, a protected carboxy group, amino, a protected amino group, cyano, phosphono, a protected phosphono group and a heterocyclic group which may have suitable substituent(s), Ra is a protected amino group, Rb is a protected carboxy group, Rc and Rd are combined to form oxo or a protected oxo group, and X1 is halogen, and R2 is carboxy or a protected carboxy group, provided that, when RC is amino, then R2 is carboxy, or a salt thereof.
A total synthesis of nocardicins
Isenring,Hofheinz
, p. 2591 - 2597 (2007/10/02)
Four-component-condensation of D-isoserine or L-isoserine, diphenylmethyl isocyanide and p-(benzyloxy)benzaldehyde was used to construct a functionalized β-lactam ring system which was transformed in 4 steps into 3-aminocardicinic acid. A protected side c
