1237492-60-2Relevant articles and documents
Synthesis, antiprolife ativeactivity and inhibition of tubulinpolymerization byanthracenone-based oxime derivatives
Surkau, Georg,B?hm, Konrad J.,Müller, Klaus,Prinz, Helge
experimental part, p. 3354 - 3364 (2010/08/06)
A series of anthracenone-based oxime ethers and-esters were synthesized in order to evaluate their antiproliferative activity. Several investigated compounds displayed strong antiproliferative activity against K562 leukemia cells and proved to be strong inhibitors of tubulin polymerization. In this context,anthracenone-based oxime ethers and-esters are considered to contribute to the development of novel antiproliferative drugs,based on tubulin interaction.