123776-23-8Relevant academic research and scientific papers
γ-Lithioalkoxides via Reductive Lithiation of Oxetanes by Aromatic Radical Anions
Mudryk, Boguslaw,Cohen, Theodore
, p. 5657 - 5659 (2007/10/02)
Oxetanes are cleaved at 0 deg C in tetrahydrofuran by lithium 4,4'-di-tert-butylbiphenylide, giving lithium γ-lithioalkoxides which can provide 2-substituted tetrahydrofurans by trapping with aldehydes and ketones followed by acid cyclization of the resulting 1,4-diols; the cuprates of these dianions undergo conjugate addition and nucleophilic substitution reactions.
