123784-07-6

Basic information

• Product Name: 2-(5-BROMO-2-THIENYL)PYRIDINE
• Synonyms: 2-(5-BROMOTHIEN-2-YL)PYRIDINE;2-(5-BROMO-2-THIENYL)PYRIDINE;BUTTPARK 36\04-38;2-(5-broMo-thiophen-2-yl)pyridine
• CAS NO: 123784-07-6
• Molecular Formula: C₉H₆BrNS
• Molecular Weight: 240.12
• Mol File: 123784-07-6.mol

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 301.7 °C at 760 mmHg
• Flash Point: 136.2 °C
• Appearance: /
• Density: 1.563 g/cm³
• Vapor Pressure: 0.00186mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.80±0.19(Predicted)
• CAS DataBase Reference: 2-(5-BROMO-2-THIENYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-BROMO-2-THIENYL)PYRIDINE(123784-07-6)
• EPA Substance Registry System: 2-(5-BROMO-2-THIENYL)PYRIDINE(123784-07-6)

Safety Data

• Hazard Codes: T
• Statements: 20/21/22-36/37/38-41-37/38-25
• Safety Statements: 26-36/37/39-45-39
• Hazardous Substances Data: 123784-07-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-(5-BROMO-2-THIENYL)PYRIDINE is used as a building block for the synthesis of various pharmaceuticals due to its unique structure and potential biological activity. Its diverse reactivity allows for the development of new chemical reactions and complex molecule synthesis, contributing to the creation of innovative drugs with improved therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical industry, 2-(5-BROMO-2-THIENYL)PYRIDINE serves as a starting material for the synthesis of agrochemicals. Its unique structure and properties enable the development of new compounds with enhanced pesticidal or herbicidal activities, contributing to more effective and sustainable agricultural practices.
Used in Coordination Chemistry:
2-(5-BROMO-2-THIENYL)PYRIDINE is utilized as a ligand in coordination chemistry. Its ability to form stable complexes with metal ions allows for the exploration of new coordination compounds with potential applications in catalysis, materials science, and other fields.
Used in the Synthesis of Functionalized Heterocycles:
As a versatile building block, 2-(5-BROMO-2-THIENYL)PYRIDINE is employed in the synthesis of other functionalized heterocycles. These heterocycles can be further modified or used as intermediates in the development of new compounds with specific properties and applications in various industries.

InChI:InChI=1/C9H6BrNS/c10-9-5-4-8(12-9)7-3-1-2-6-11-7/h1-6H

Upstream product

• 19162-80-2 5-bromo-[2]thienyl lithium 
• 63755-30-6 N-ethoxycarbonylpyridinium chloride 
• 123817-34-5 2-(2-thienyl)pyridine dibromide 
• 3319-99-1 2'-(2-thienyl)pyridine 
• 2160-62-5 5-bromo-2-thiophenecarbonitrile 
• 74-86-2 acetylene 
• 1003-31-2 thiophene-2-carbonitrile 
• 109-04-6 2-bromo-pyridine 
• 29504-81-2 5-iodo-2-bromothiophene 

Downstream Products

• 119082-97-2 5-(pyridin-2-yl)thiophene-2-carboxylic acid 
• 132706-12-8 2-(pyridin-2-yl)-5-thiophene carbaldehyde 
• 132464-90-5 2-(5-ethynylthiophen-2-yl)pyridine 
• 132464-79-0 4-(2-Chloro-phenyl)-9-methyl-2-[2-(5-pyridin-2-yl-thiophen-2-yl)-ethyl]-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene 
• 132464-71-2 4-(2-Chloro-phenyl)-9-methyl-2-(5-pyridin-2-yl-thiophen-2-ylethynyl)-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene 
• 1446418-83-2 1-(3-chloro-5'-pyridin-2-yl-[2,2']bithiophenyl-5-yl)ethanone 
• 1446418-91-2 1-[4-(2-pyridin-2-ylthiophen-3-yl)phenyl]propan-1-one 
• 1446418-93-4 C₁₆H₁₀N₂S 
• 1446418-87-6 2-[5-(3,5-dimethylisoxazol-4-yl)thiophen-2-yl]pyridine 
• 3319-99-1 2'-(2-thienyl)pyridine 
• 138565-27-2 2-phenyl-5-(pyridin-2-yl)thiophene 

Relevant articles and documents

β-Strand Mimicry: Exploring Oligothienylpyridine Foldamers

Protein–protein interactions (PPIs) are involved in many cellular processes; consequently, the discovery of small molecules as modulators of PPIs has become an important challenge in medicinal chemistry. Structural mimetics of α-helices, β-turns or β-strands could maintain or restore biological functions and should possess biological activity. At this time, the most challenging classes of PPIs are those mediated by β-sheet interactions, which are implicated in a number of diseases. Only a few β-strand mimics have been published to date. This study presents an evaluation of oligothienylpyridyl scaffolds in view of their ability for β-strand mimicry. In this study, theoretical ring twist angle predictions for these scaffolds have been validated by X-ray diffraction and molecular dynamics simulations with NMR constraints. Careful choice of substituent and heavy-atom positions in the foldamer units opens the way to produce reasonably coplanar compounds mimicking β-strand side-chain distribution.

COMPOUND ACTING AS ANTIBIOTICS

The present invention provides a novel antibiotic compound represented by the following formula (I), a pharmaceutically acceptable salt thereof, an ester thereof, a prodrug thereof, a solvate thereof, or a deuterated analog thereof, or a stereoisomer thereof. The compound of the present invention exhibits excellent antibacterial activity, especially against Gram bacteria. wherein each group is defined as in the description.

Regioselective oxidative Pd-catalysed coupling of alkylboronic acids with pyridin-2-yl-substituted heterocycles

A total of 19 alkylated heterocycles (thiophenes, benzothiophenes, pyrroles, furans) were prepared (36-99% yield) from the respective pyridin-2-yl-substituted precursors employing alkylboronic acids as the C-H alkylating reagents in an oxidative (Ag2

6-11 Bicyclic ketolide derivatives

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

6-11 bicyclic ketolide derivatives

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

6-11 BICYCLIC KETOLIDE DERIVATIVES

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: (I) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the afor

6-11 BICYCLIC KETOLIDE DRIVATIVES

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: Formule (I) which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising

6-11 Bicyclic ketolide derivatives

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

6-11 BICYCLIC KETOLIDE DERIVATIVES

The present invention discloses compounds of formula (I), or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforem

Process for the preparation of 6-O-propargyl erythromycin derivatives

Disclosed herein is a process for the preparation of erythromycin derivatives, or pharmaceutically acceptable salts thereof, which contain an optionally substituted propargyl group at the 6-O-position.