123784-07-6

Basic information

• Product Name: 2-(5-BROMO-2-THIENYL)PYRIDINE
• Synonyms: 2-(5-BROMOTHIEN-2-YL)PYRIDINE;2-(5-BROMO-2-THIENYL)PYRIDINE;BUTTPARK 36\04-38;2-(5-broMo-thiophen-2-yl)pyridine
• CAS NO: 123784-07-6
• Molecular Formula: C₉H₆BrNS
• Molecular Weight: 240.12
• Mol File: 123784-07-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: 87 °C
• Boiling Point: 301.7 °C at 760 mmHg
• Flash Point: 136.2 °C
• Appearance: /
• Density: 1.563 g/cm³
• Vapor Pressure: 0.00186mmHg at 25°C
• Refractive Index: 1.635
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 2.80±0.19(Predicted)
• CAS DataBase Reference: 2-(5-BROMO-2-THIENYL)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-BROMO-2-THIENYL)PYRIDINE(123784-07-6)
• EPA Substance Registry System: 2-(5-BROMO-2-THIENYL)PYRIDINE(123784-07-6)

Safety Data

• Hazard Codes: T
• Statements: 20/21/22-36/37/38-41-37/38-25
• Safety Statements: 26-36/37/39-45-39
• Hazardous Substances Data: 123784-07-6(Hazardous Substances Data)

Usage

General Description

2-(5-Bromo-2-thienyl)pyridine is a chemical compound with the molecular formula C9H6BrNS. It is a heterocyclic organic compound containing a pyridine ring fused to a thiophene ring with a bromine substituent at the 5-position of the thiophene ring. 2-(5-BROMO-2-THIENYL)PYRIDINE is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals due to its diverse reactivity and potential biological activity. It is also used as a starting material for the synthesis of other functionalized heterocycles and as a ligand in coordination chemistry. Additionally, its unique structure and properties make it a valuable tool in the development of new chemical reactions and complex molecule synthesis.

InChI:InChI=1/C9H6BrNS/c10-9-5-4-8(12-9)7-3-1-2-6-11-7/h1-6H

Upstream product

• 19162-80-2 5-bromo-[2]thienyl lithium 
• 63755-30-6 N-ethoxycarbonylpyridinium chloride 
• 123817-34-5 2-(2-thienyl)pyridine dibromide 
• 3319-99-1 2'-(2-thienyl)pyridine 
• 2160-62-5 5-bromo-2-thiophenecarbonitrile 
• 74-86-2 acetylene 
• 1003-31-2 thiophene-2-carbonitrile 
• 109-04-6 2-bromo-pyridine 
• 29504-81-2 5-iodo-2-bromothiophene 

Downstream Products

• 119082-97-2 5-(pyridin-2-yl)thiophene-2-carboxylic acid 
• 1446418-83-2 1-(3-chloro-5'-pyridin-2-yl-[2,2']bithiophenyl-5-yl)ethanone 
• 1446418-91-2 1-[4-(2-pyridin-2-ylthiophen-3-yl)phenyl]propan-1-one 
• 1446418-93-4 C₁₆H₁₀N₂S 
• 1446418-87-6 2-[5-(3,5-dimethylisoxazol-4-yl)thiophen-2-yl]pyridine 
• 3319-99-1 2'-(2-thienyl)pyridine 
• 138565-27-2 2-phenyl-5-(pyridin-2-yl)thiophene 
• 132464-71-2 4-(2-Chloro-phenyl)-9-methyl-2-(5-pyridin-2-yl-thiophen-2-ylethynyl)-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene 
• 132464-79-0 4-(2-Chloro-phenyl)-9-methyl-2-[2-(5-pyridin-2-yl-thiophen-2-yl)-ethyl]-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulene 
• 132464-90-5 2-(5-ethynylthiophen-2-yl)pyridine 
• 132706-12-8 2-(pyridin-2-yl)-5-thiophene carbaldehyde 

Relevant articles and documents

β-Strand Mimicry: Exploring Oligothienylpyridine Foldamers

Protein–protein interactions (PPIs) are involved in many cellular processes; consequently, the discovery of small molecules as modulators of PPIs has become an important challenge in medicinal chemistry. Structural mimetics of α-helices, β-turns or β-strands could maintain or restore biological functions and should possess biological activity. At this time, the most challenging classes of PPIs are those mediated by β-sheet interactions, which are implicated in a number of diseases. Only a few β-strand mimics have been published to date. This study presents an evaluation of oligothienylpyridyl scaffolds in view of their ability for β-strand mimicry. In this study, theoretical ring twist angle predictions for these scaffolds have been validated by X-ray diffraction and molecular dynamics simulations with NMR constraints. Careful choice of substituent and heavy-atom positions in the foldamer units opens the way to produce reasonably coplanar compounds mimicking β-strand side-chain distribution.

Regioselective oxidative Pd-catalysed coupling of alkylboronic acids with pyridin-2-yl-substituted heterocycles

A total of 19 alkylated heterocycles (thiophenes, benzothiophenes, pyrroles, furans) were prepared (36-99% yield) from the respective pyridin-2-yl-substituted precursors employing alkylboronic acids as the C-H alkylating reagents in an oxidative (Ag2

6-11 bicyclic ketolide derivatives

The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.