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Usage

Uses

Used in Medical Applications:
NaN(18)O2 is used as a quantification agent for the measurement of nitrite levels in human whole blood, erythrocytes, and plasma. The presence of the 18O isotope allows for accurate detection and quantification of nitrite, which is essential in understanding various physiological processes and diagnosing certain medical conditions.
Used in Research Applications:
In the field of research, NaN(18)O2 is used as a tracer for studying the metabolism and distribution of nitrite in the body. The stable isotope of oxygen enables researchers to track the compound's behavior and interactions with other molecules, providing valuable insights into its role in biological systems.
Used in Analytical Chemistry:
NaN(18)O2 is employed as a reference material in analytical chemistry for the development and validation of methods for nitrite detection and quantification. The stable isotope serves as a reliable internal standard, ensuring the accuracy and precision of the measurements.
Used in Environmental Applications:
In environmental science, NaN(18)O2 can be used to study the cycling of nitrogen compounds in ecosystems, particularly in aquatic systems where nitrite plays a crucial role in the nitrogen cycle. The labeled compound helps researchers understand the processes involved in nitrite formation, transformation, and removal from the environment.
Used in Food Industry:
In the food industry, NaN(18)O2 can be used to study the effects of nitrite additives on food preservation and safety. The labeled compound can help researchers investigate the formation of potentially harmful nitrosamines and other nitrite-related compounds, leading to the development of safer and more effective preservation methods.

Upstream product

• 14797-71-8 ¹⁸O-labeled water 
• 7632-00-0 sodium nitrite 

Relevant academic research and scientific papers

Base-catalyzed nitrito to nitro linkage isomerization of cobalt(III), rhodium(III), and iridium(III) pentaammine complexes

The nitrito ions [M(NH3)5(ONO)]2+ (M = Co(III), Rh(III), or Ir(III)) rearrange to their nitro forms [M(NH3)5(NO2)]2+ in aqueous base according to the rate law kobsd = ks + kOH[OH-] where at μ = 1.0 M, 25.0°C: ks = 6.9 (±0.2) × 10-5 s-1, ΔHs≠ = 95 ± 4 kJ mol-1, ΔSs≠ = -4 ± 12 J K-1 mol-1, kOH = 5.9 (±0.2) × 10-3 dm3 mol-1 s-1, ΔHOH≠ = 110 ± 1 kJ mol-1, ΔSOH≠ = +82 ± 4 J K-1 mol-1, M = Co; ks = 9.6 (±0.2) × 10-4 s-1, ΔHs≠ = 85 ± 2.5 kJ mol-1, ΔSx≠ = -18 ± 9 J K-1 mol-1, kOH = 7.6 (±0.2) × 10-3 dm3 mol-1 s-1, ΔHOH≠ = 96 ± 2 kJ mol-1, ΔSOH≠ = +38 ± 6 J K-1 mol-1, M = Rh; ks = 3.0 (±0.1) × 10-5 s-1, ΔHs≠ = 94 ± 2 kJ mol-1, = 16 ± 5 J K-1 mol-1, kOH = 2.7 (±0.1) × 10-5 dm3 mol-1 s-1, ΔHOH≠ = 109 ± 2 kJ mol-1, ΔSOH≠ = 34 ± 6 J K-1 mol-1, M = Ir. For the cobalt complex the pressure dependence of kOH (ΔV≠ = +27 (±1.4) cm3 mol-1, Δβ≠ = 5 (±2) cm-3 kbar-1 mol-1) points to a conjugate base preequilibrium for the base-catalyzed path. The metal ion dependence of kOH/ks (95:9:1 for Co:Rh:lr) is also consistent with a conjugate base process. [Co(NH3)5(ONO)]2+ rearranges to [Co(NH3)5(NO2)]2+ without exchange of oxygen with H218O, 18OH-, or free N18O2- (1 M); both the ks and kOH paths are intramolecular. Up to 1 M OH there is 3)5(OH)]2+. Both rate constants ks and kOH for M = Co decrease with increasing ionic strength (25°C, 105ks = 6.9, 7.4, 103kOH = 5.9, 14.5; μ = 1.0, 0.1, respectively). cis- and trans-[Co(en)2(ONO)2]+ and [Co(en)2(ONO)(NO2)]+ rearrange by both pathways to the dinitro complexes without change in configuration, and (+)cis-[Co(en)2(ONO)(NO2)]+ rearranges without loss of chirality. For the kOH reaction these results also differ from the normal substitution chemistry where there is some steric change. In addition to the O to N rearrangement, a much faster O to O scrambling process has been identified for the cobalt complex using 18O tracers.

Hydroxylamine as an oxygen nucleophile: Substitution of sulfonamide by a hydroxyl group in benzothiazole-2-sulfonamides

Benzothiazole-2-sulfonamides react with an excess of hydroxylamine in aqueous solutions to form 2-hydroxybenzothiazole, sulfur dioxide, and the corresponding amine. Mechanistic studies that employ a combination of structure-reactivity relationships, oxygen labeling experiments, and (in)direct detection of intermediates and products reveal that the reaction proceeds via oxygen attack, and that oxygen incorporated in the 2-hydroxybenzothiazole product derives from hydroxylamine. The reaction, which is performed under mild conditions, can be used as a deprotection method for cleavage of benzothiazole-2-sulfonyl-protected amino acids.