7632-00-0

Basic information

• Product Name: Sodium nitrite
• Synonyms: Natrium nitrit;Nitrous acid sodium salt;Dusitan sodny;Anti-Rust;Nitrite de sodium;Diazotizing salts;Erinitrit;NCI-C02084;Filmerine;Synfat 1004;Nitrous acid, sodium salt;M 138C;Sodium Nitrite for Industrial use;Industrial Sodium Nitrite
• CAS NO: 7632-00-0
• Molecular Formula: NNaO₂
• Molecular Weight: 68.99527
• EINECS: 231-555-9
• Mol File: 7632-00-0.mol
• Article Data: 189

Chemical Properties

• Melting Point: 271℃
• Boiling Point: 320 °C
• Appearance: white to off-white powder
• Density: 2.168 g/cm³
• Water Solubility: 820 g/L (20℃)
• CAS DataBase Reference: Sodium nitrite(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium nitrite(7632-00-0)
• EPA Substance Registry System: Sodium nitrite(7632-00-0)

Safety Data

• Hazard Codes: O:Oxidizing agent
• Statements: R25:; R50:; R8:
• Safety Statements: S45:; S61:
• RIDADR: 1500
• HazardClass: 5.1
• PackingGroup: III
• Hazardous Substances Data: 7632-00-0(Hazardous Substances Data)

Usage

InChI:InChI=1/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1

Synthetic route

sodium nitrate (7631-99-4) → sodium nitrite (7632-00-0)

difluoro-nitro-methane (1493-05-6) + sodium ethanolate (141-52-6) → sodium fluoride + sodium nitrite (7632-00-0) + Diethyl carbonate (105-58-8)

Conditions	Yield
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:4), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 81% B 78% C 7%
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile 1:2, reacting (-10°C for 10-15 min), stirring(0°C for 1 h), reaction mixt. leaving overnight at -20°C; salts. ppt. sepn. (CH2Cl2 addn., cooling), ppt. treatment with boiling ethanol, NaNO2 pptn. from filtrate, aq. H2SO4 addn. to filtrate, org. layer sepn., aq. layer extn. (CH2Cl2), ext. drying (MgSO4), distn. lead to(EtO)2CO; chem. and GLC anal.;	A 48% B 62% C 12%
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:1), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 18% B 26% C 9%
In ethanol; N,N-dimethyl-formamide alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (DMF) (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;

sodium sulfide + calcium(II) nitrate (13477-34-4) + sodium sulfite (7757-83-7) → calcium sulfate + sodium sulfate (7757-82-6) + sodium nitrite (7632-00-0)

Conditions	Yield
In neat (no solvent) formation at heating under glowing;;	A n/a B n/a C 60%

difluoro-nitro-methane (1493-05-6) + sodium ethanolate (141-52-6) → carbonate(2-) (3812-32-6) + sodium fluoride + sodium nitrite (7632-00-0) + Diethyl carbonate (105-58-8)

Conditions	Yield
In ethanol byproducts: NO3(1-); alkoxide soln. addn. to F2C(NO2)2 soln. (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 8% B 43% C n/a D 14%

fluorotrinitromethane (21824-10-2) + sodium ethanolate (141-52-6) → ethoxyfluorodinitromethane (17021-83-9) + sodium fluoride + sodium nitrite (7632-00-0) + Diethyl carbonate (105-58-8)

Conditions	Yield
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. (dropwise) to FC(NO2)3 soln. (CH2Cl2) (molar ratio FC(NO2)3:nucleophile=1:2), stirring (0-5°C for 1.5 h), 5%H2SO4 soln. addn., extn. (CH2Cl2), drying (MgSO4); residue distn. (vac.), ppt. sepn.; chem. and GLC anal., IR spectroscopy;	A 42% B n/a C n/a D 6.8%

N,N-bis(methylsulfonyl)hydroxylamine (96088-55-0) → sodium methansulfinate (20277-69-4) + sodium nitrite (7632-00-0)

Conditions	Yield
With sodium hydroxide In water Product distribution; Mechanism; hydrolysis with basic, neutral and acidic aqu. solutions, also in addition of NaN3 (other products);

sodium hydroxide (1310-73-2) + Nitrogen dioxide (10102-44-0) → sodium nitrite (7632-00-0)

sodium peroxide + N-oxo-N-nitrosoamine (16824-89-8, 12533-50-5) → sodium nitrite (7632-00-0)

Conditions	Yield
In neat (no solvent) at 150°C;;

sodium hyponitrite + Nitrogen dioxide (10102-44-0) → sodium nitrate (7631-99-4) + sodium nitrite (7632-00-0)

Conditions	Yield
oxidation;
oxidation;

sodium azide + oxygen → sodium nitrite (7632-00-0)

Conditions	Yield
With sodium In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;;
With Na In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;;

sodium azide + Nitryl chloride → sodium nitrite (7632-00-0)

sodium azide + barium peroxide (1304-29-6) → sodium nitrite (7632-00-0)

Conditions	Yield
With sodium In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;;
With Na In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;;

sodium amide + nitrosylchloride (2696-92-6) → sodium nitrite (7632-00-0)

Conditions	Yield
In neat (no solvent)
In neat (no solvent)

sodium sulfide + sodium nitrate (7631-99-4) + sulfur dioxide (7446-09-5) → sodium nitrite (7632-00-0)

Conditions	Yield
In melt byproducts: Na2SO4, Na2SO3; in melt at 330°C;

sodium nitrate (7631-99-4) + hydrogen cation → ammonia (7664-41-7) + hydrogen (1333-74-0) + sodium nitrite (7632-00-0)

Conditions	Yield
In water byproducts: H2O; Electrolysis; electrolysis (1.25V vs. SCE), (Bu4N)4(MoFe3S4(SC6H5)3(O2C6Cl4))2 modified glassy carbon electrode, pH 10;

sodium nitrate (7631-99-4) + nitric acid (7697-37-2) → sodium nitrite (7632-00-0)

Conditions	Yield
In acetic acid Kinetics; other Radiation; γ-ray radiation of (60)Co; at 23°C; dose rate of 1.2 Gy s**(-1);

ammonium nitrate + sodium (7440-23-5) → sodium hyponitrite + disodium nitrite + sodium hydroxide (1310-73-2) + sodium nitrite (7632-00-0)

Conditions	Yield
In ammonia
In ammonia NH3 (liquid);

Iron(III) nitrate nonahydrate + sodium (7440-23-5) → hydrogen (1333-74-0) + iron (7439-89-6) + sodium amide + sodium hydroxide (1310-73-2) + sodium nitrite (7632-00-0)

Conditions	Yield
In ammonia -33°C;
In ammonia NH3 (liquid); -33°C;

nitrogen(II) oxide (10102-43-9) + sodium (7440-23-5) → sodium hyponitrite + sodium nitrite (7632-00-0)

Conditions	Yield
above 190°C;
above 190°C;

nitrogen(II) oxide (10102-43-9) + sodium (7440-23-5) → sodium nitrate (7631-99-4) + sodium nitrite (7632-00-0)

Conditions	Yield
heating with dry NO;

oxygen (80937-33-3) + sodium (7440-23-5) → sodium hydroxide (1310-73-2) + sodium nitrite (7632-00-0)

Conditions	Yield
In ammonia slow O2 flow;
In ammonia NH3 (liquid); slow O2 flow;

sodium nitrate (7631-99-4) + sodium (7440-23-5) → sodium nitrite (7632-00-0)

Conditions	Yield
In ammonia molar ratio of Na:NaNO3 = 2:1;
In ammonia NH3 (liquid); molar ratio of Na:NaNO3 = 2:1;

sodium (7440-23-5) + Nitrogen dioxide (10102-44-0) → sodium nitrite (7632-00-0)

Conditions	Yield
at 22-105°C; pressure of NO2 less then 600 torr;
at 22-105°C; pressure of NO2 less then 600 torr;

sodium (7440-23-5) + Nitrogen dioxide (10102-44-0) → sodium nitrate (7631-99-4) + sodium nitrite (7632-00-0)

Conditions	Yield
burning of Na in NO2 atmosphere;
slow oxidation of Na at the surface, above the melting point;
slow oxidation of Na at the surface, above the melting point;
burning of Na in NO2 atmosphere;

ammonia (7664-41-7) + sodium carbonate (497-19-8) + oxygen → sodium nitrite (7632-00-0)

Conditions	Yield
In neat (no solvent) 2 volumeparts NH3 are combusted with 3 volumeparts O2; formed N2O3 (NO and NO2) is absorped by Na2CO3;;
In neat (no solvent) 2 volumeparts NH3 are combusted with 3 volumeparts O2; formed N2O3 (NO and NO2) is absorped by Na2CO3;;

Nitryl chloride + sodium hydroxide (1310-73-2) → sodium nitrite (7632-00-0)

dinitrogen trioxide (10544-73-7) → sodium nitrite (7632-00-0)

Conditions	Yield
With sodium hydroxide In water byproducts: H2O; absorption of nitrosic gases in alkaline soln.;
With NaOH In water byproducts: H2O; absorption of nitrosic gases in alkaline soln.;

potassium nitrate + sodium hydroxide (1310-73-2) → sodium nitrite (7632-00-0)

Conditions	Yield
With cast iron In melt melting of 500 kg KNO3 and 500 kg NaOH together; reaction of the melt with finely powdered cast iron for 5-6 h;;

sodium nitrite (7632-00-0) → nitrogen(II) oxide (10102-43-9)

Conditions	Yield
With acetic acid; potassium iodide In water Product distribution / selectivity;	100%
With sulfuric acid; water at 10℃; under 375.038 Torr; for 1.38889E-05h; Reagent/catalyst; Temperature; Pressure; Time;	99.99%
With maleic acid; ascorbic acid In water Product distribution / selectivity;

sulfur (7704-34-9) + sodium nitrite (7632-00-0) → sodium thiosulfate

Conditions	Yield
In N,N-dimethyl-formamide byproducts: N2O; at about 80°C, under N2 or CO2, cooling, separation of Na2S2O3;; washing with acetone, analytically pure;;	100%
In further solvent(s) byproducts: N2O; solvent: dimethyl acetamide, at about 80°C, under N2 or CO2, cooling, separation of Na2S2O3;; washing with acetone, analytically pure;;	100%

fac-triaquotrinitroiridium(III) + sodium nitrite (7632-00-0) → trisodium hexanitroiridate(III)

Conditions	Yield
In not given 100°C, 1 h;	100%

+ sodium nitrite (7632-00-0) → αβ-s-{Co(2-methyl-3,6,9-triazaundec-2-ene-1,11-diamine)NO2}(ZnCl4) (117229-37-5)

Conditions	Yield
With ZnCl2 In hydrogenchloride soln. of Co-complex in HCl added NaNO2, heated for 20 min; soln. poured into 2-propanol/acetone (contained ZnCl2), cooled, powder collected, washed (acetone, Et2O), elem. anal.;	100%

αβ-i-{Co(3,6,9-triazaundec-2-ene-1,11-diamine)Cl}(ClO4)2 (117229-25-1) + sodium nitrite (7632-00-0) → αβ-i-{Co(3,6,9-triazaundec-2-ene-1,11-diamine)NO2}(ZnCl4) (117229-27-3)

Conditions	Yield
With ZnCl2 In perchloric acid soln. of Co-complex in HClO4 added NaNO2, heated for 20 min, poured into a acetone/2-propanol mixture with ZnCl2; cooled to 0°C, washed (acetone Et2O), elem. anal.;	100%

tetrakis(methylisocyanide) boron triflate + sodium carbonate (497-19-8) + sodium nitrite (7632-00-0) → 3Na(1+)*(B(CO2)2(CO2H)2)(3-)*2H2O=Na3(B(CO2)2(CO2H)2)*2H2O

Conditions	Yield
In ethanol; sulfuric acid; water aq. H2SO4; B(CNCH3)4(CF3SO3)3 dissolved in H2O and cooled to 0°C, addn. of aq. mixt. of NO and NO2 prepd. from NaNO2, H2SO4, and H2O over 4 h, stirred for 16 h at room temp., addn. of Na2CO3 and ethanol; pptn., filtered, dissolved (H2O), soln. saturated with CO2, addn. of ethanol, pptn., filtered, washed (ethanol, diethyl ether);	100%

[N,N'-bis(2-methyl-2-amino-κN-propyl)oxamidato-κ(2)N,N']copper(II) (252258-61-0) + copper(II) nitrate + sodium nitrite (7632-00-0) → catena-poly[copper(II)-μ-[N,N'-bis(2-methyl-2-aminopropyl)oxamido(2-)-N,N',O':N'',N''',O]copper(II)-di-μ-nitrito(-)-O] (252258-63-2)

Conditions	Yield
In methanol; water addn. of aq. Cu(NO3)2 and then aq. NaNO2 to Cu-complex (in MeOH) with stirring (pptn.); collection (filtration), washing (MeOH, Et2O), drying in air; elem. anal.;	98%

tetrafluoroboric acid + 2,6-dimethoxyaniline (2734-70-5) + sodium nitrite (7632-00-0) → 2,6-dimethoxybenzenediazonium tetrafluoroborate

Conditions	Yield
In water at 0℃; for 0.75h;	98%

tetrafluoroboric acid + 3,4,5-Trimethoxyaniline (24313-88-0) + sodium nitrite (7632-00-0) → 3,4,5-trimethoxybenzenediazonium tetrafluoroborate

Conditions	Yield
In water at 0℃; for 0.5h;	98%
Stage #1: tetrafluoroboric acid; 3,4,5-Trimethoxyaniline In water at 0℃; for 0.25h; Stage #2: sodium nitrite In water at 0℃; for 0.5h;

copper(II) perchlorate hexahydrate + 3,3'-Diamino-N-methyldipropylamine (105-83-9) + sodium nitrite (7632-00-0) → [Cu(3,3'-diamino-N-methyldipropylamine)(ONO)(H2O)]ClO4 (890850-35-8)

Conditions	Yield
In methanol soln. of Cu salt added to soln. of org. compd., hot soln. of NaNO2 addeddropwise, heated for 10 min; hot filtered, allowed to crystallize at room temp., filtered, washed with ether, air-dried; elem. anal.;	97%

(2-aza-5,10,15,20-tetraphenyl-21-carbaporphyrinato)FeBr + sodium nitrite (7632-00-0) → [Fe(CTPP)NO]

Conditions	Yield
1 equiv of NaNO2 under inert atm. at ambient temp.; silica gel column chromy. in a room atm.;	97%

zinc perchlorate + 6,16,2,5-tribenzena(1,4)-1,4,8,11,14,18,23,27-octaazabicyclo[9.9.9]nonacosaphane (119142-71-1) + sodium nitrite (7632-00-0) → [pCZn2(μ-ONO)](ClO4)3

Conditions	Yield
Stage #1: zinc perchlorate; 6,16,2,5-tribenzena(1,4)-1,4,8,11,14,18,23,27-octaazabicyclo[9.9.9]nonacosaphane In methanol at 20℃; for 0.5h; Stage #2: sodium nitrite In methanol for 12h;	97%

[Ru(N,N-dimethyl-4,6-di(pyridin-2-yl)-1,3,5-triazin-2-amine)(2,2'-bipyridine)(CH3CN)](ClO4)2 + sodium nitrite (7632-00-0) → [Ru(N,N-dimethyl-4,6-di(pyridin-2-yl)-1,3,5-triazin-2-amine)(2,2'-bipyridine)(NO2)](ClO4)

Conditions	Yield
In water; acetone for 12h; Reflux; Inert atmosphere;	96.89%

[Ru(η2-C6HCPhCH-1-O-2-CHNHEt-3-NO2-4-Me-5)(PPh3)2(CO)Cl] (350832-46-1) + sodium nitrite (7632-00-0) → [Ru(η2-C6HCPhCH-1-O-2-CHNHEt-3-NO2-4-Me-5)(PPh3)2(CO)(NO2)]

Conditions	Yield
In dichloromethane; water; acetone aq. soln. of NaNO2 added dropwise to Ru complex soln. in CH2Cl2/acetone,stirred for 5 h; solvent removed (vac.), filtered, washed (H2O), dried (vac.); elem. anal.;	96%

tetrafluoroboric acid + sulfamethizole (144-82-1) + sodium nitrite (7632-00-0) → C9H8N5O2S2(1+)*BF4(1-)

Conditions	Yield
In water at 0℃; for 0.75h; Inert atmosphere;	96%

hydrogenchloride (7647-01-0) + ruthenium trichloride + sodium nitrite (7632-00-0) → ruthenium(II)nitrosyl trichloride

Conditions	Yield
In water for 4h; Heating / reflux;	95%

C6F5Ni(P(CH3)2C6H5)2Br + sodium nitrite (7632-00-0) → C6F5Ni(P(CH3)2C6H5)2NO2

Conditions	Yield
In water; acetone prepn. from C6F5Ni(CH3)2C6H5)2Br and excess of NaNO2 in aq. acetone under reflux;;	95%
In water; acetone prepn. from C6F5Ni(CH3)2C6H5)2Br and excess of NaNO2 in aq. acetone under reflux;;	95%

Upstream product

• 104-88-1 4-Chlorobenzaldehyde 
• 124-38-9 CARBON DIOXIDE 
• 1317-36-8 Lead monoxide 
• 7782-77-6 NITROUS ACID 
• 7631-99-4 Sodium nitrate 
• 1336-21-6 Ammonium hydroxide 
• 497-19-8 Sodium carbonate 

Downstream Products

• 20005-42-9 5-(4-Bromophenyl)furfural 
• 12238-01-6 Reactive Red 15 
• 70315-68-3 3-BROMO-6-NITROINDAZOLE 
• 2942-42-9 7-Nitroindazole 
• 13603-44-6 4-Hydroxy-2,6-dimethylpyridine 
• 3034-48-8 2-Bromo-5-nitrothiazole 
• 25646-77-9 4-(N-Ethyl-N-2-hydroxyethyl)-2-methylphenylenediamine sulfate 
• 1468-26-4 8-AZAXANTHIN 
• 52189-63-6 1,3-DIMETHOXY-5-FLUOROBENZENE 
• 403-45-2 6-Fluoronicotinic acid 
• 392-85-8 2-Fluorobenzotrifluoride 
• 402-44-8 4-Fluorobenzotrifluoride 
• 7597-18-4 6-Nitroindazole 
• 2198-58-5 N,N-DIETHYL-P-PHENYLENEDIAMINE MONOHYDROCHLORIDE 
• 15854-87-2 4-Iodopyridine 
• 2052-25-7 Mordant Black 9 
• 34461-00-2 NITROMALONALDEHYDE SODIUM 
• 306935-95-5 5-[4-(TRIFLUOROMETHOXY)PHENYL]-2-FURALDEHYDE 
• 407-22-7 2-Fluoro-6-methylpyridine 
• 4498-68-4 1H-INDAZOLE-3-CARBOXYLIC ACID ETHYL ESTER 
• 5280-68-2 Pigment Red 146 
• 19335-11-6 5-AMINOINDAZOLE 
• 306936-05-0 5-[4-FLUORO-3-(TRIFLUOROMETHYL)PHENYL]-2-FURALDEHYDE 
• 17407-55-5 (S)-(+)-2-HYDROXY-3-METHYLBUTYRIC ACID 
• 4812-45-7 3-CHLORO-5-NITRO-1H-INDAZOLE 
• 138-60-3 Chelidamic acid 
• 401-80-9 3-Fluorobenzotrifluoride 
• 23244-88-4 6-Hydroxyindazole 
• 188554-13-4 2-HYDROXY-4-PYRIDINECARBOXALDEHYDE 
• 188712-74-5 9-DIETHYLAMINO-2-HYDROXY-5H-BENZ(A)- 
• 5468-75-7 Pigment Yellow 14 
• 50264-88-5 1H-INDAZOLE-3-CARBONITRILE 
• 2369-19-9 2-Fluoro-5-methylpyridine 
• 7238-62-2 ETHYL 2-CHLORO-4-METHYL-1,3-THIAZOLE-5-CARBOXYLATE 
• 2051-79-8 4-(N,N-Diethyl)-2-methyl-p-phenylenediamine monohydrochloride 
• 6064-63-7 DL-ALPHA-HYDROXYCAPROIC ACID, 95 

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