7632-00-0

Basic information

• Product Name: Sodium nitrite
• Synonyms: Natrium nitrit;Nitrous acid sodium salt;Dusitan sodny;Anti-Rust;Nitrite de sodium;Diazotizing salts;Erinitrit;NCI-C02084;Filmerine;Synfat 1004;Nitrous acid, sodium salt;M 138C;Sodium Nitrite for Industrial use;Industrial Sodium Nitrite
• CAS NO: 7632-00-0
• Molecular Formula: NNaO₂
• Molecular Weight: 68.99527
• EINECS: 231-555-9
• Mol File: 7632-00-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 271℃
• Boiling Point: 320 °C
• Appearance: white to off-white powder
• Density: 2.168 g/cm³
• Water Solubility: 820 g/L (20℃)
• CAS DataBase Reference: Sodium nitrite(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium nitrite(7632-00-0)
• EPA Substance Registry System: Sodium nitrite(7632-00-0)

Safety Data

• Hazard Codes: O:Oxidizing agent
• Statements: R25:; R50:; R8:
• Safety Statements: S45:; S61:
• RIDADR: 1500
• HazardClass: 5.1
• PackingGroup: III
• Hazardous Substances Data: 7632-00-0(Hazardous Substances Data)

Usage

Chemical Description

Sodium nitrite is a salt that is used as a food preservative and in the production of dyes and pharmaceuticals.

Chemical Description

Sodium nitrite is a salt that is used in various industrial processes, including the production of dyes and pharmaceuticals.

Chemical Description

Sodium nitrite and sodium azide are both inorganic compounds commonly used in organic synthesis.

Chemical Description

Sodium nitrite is a salt used as a food preservative and in the production of dyes and pharmaceuticals.

InChI:InChI=1/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1

Synthetic route

sodium nitrate (7631-99-4) → sodium nitrite (7632-00-0)

difluoro-nitro-methane (1493-05-6) + sodium ethanolate (141-52-6) → sodium fluoride + sodium nitrite (7632-00-0) + Diethyl carbonate (105-58-8)

Conditions	Yield
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:4), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 81% B 78% C 7%
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile 1:2, reacting (-10°C for 10-15 min), stirring(0°C for 1 h), reaction mixt. leaving overnight at -20°C; salts. ppt. sepn. (CH2Cl2 addn., cooling), ppt. treatment with boiling ethanol, NaNO2 pptn. from filtrate, aq. H2SO4 addn. to filtrate, org. layer sepn., aq. layer extn. (CH2Cl2), ext. drying (MgSO4), distn. lead to(EtO)2CO; chem. and GLC anal.;	A 48% B 62% C 12%
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:1), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 18% B 26% C 9%
In ethanol; N,N-dimethyl-formamide alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (DMF) (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;

sodium sulfide + calcium(II) nitrate (13477-34-4) + sodium sulfite (7757-83-7) → calcium sulfate + sodium sulfate (7757-82-6) + sodium nitrite (7632-00-0)

Conditions	Yield
In neat (no solvent) formation at heating under glowing;;	A n/a B n/a C 60%

difluoro-nitro-methane (1493-05-6) + sodium ethanolate (141-52-6) → carbonate(2-) (3812-32-6) + sodium fluoride + sodium nitrite (7632-00-0) + Diethyl carbonate (105-58-8)

Conditions	Yield
In ethanol byproducts: NO3(1-); alkoxide soln. addn. to F2C(NO2)2 soln. (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 8% B 43% C n/a D 14%

fluorotrinitromethane (21824-10-2) + sodium ethanolate (141-52-6) → ethoxyfluorodinitromethane (17021-83-9) + sodium fluoride + sodium nitrite (7632-00-0) + Diethyl carbonate (105-58-8)

Conditions	Yield
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. (dropwise) to FC(NO2)3 soln. (CH2Cl2) (molar ratio FC(NO2)3:nucleophile=1:2), stirring (0-5°C for 1.5 h), 5%H2SO4 soln. addn., extn. (CH2Cl2), drying (MgSO4); residue distn. (vac.), ppt. sepn.; chem. and GLC anal., IR spectroscopy;	A 42% B n/a C n/a D 6.8%

N,N-bis(methylsulfonyl)hydroxylamine (96088-55-0) → sodium methansulfinate (20277-69-4) + sodium nitrite (7632-00-0)

Conditions	Yield
With sodium hydroxide In water Product distribution; Mechanism; hydrolysis with basic, neutral and acidic aqu. solutions, also in addition of NaN3 (other products);

sodium hydroxide (1310-73-2) + Nitrogen dioxide (10102-44-0) → sodium nitrite (7632-00-0)

sodium peroxide + N-oxo-N-nitrosoamine (16824-89-8, 12533-50-5) → sodium nitrite (7632-00-0)

Conditions	Yield
In neat (no solvent) at 150°C;;

sodium hyponitrite + Nitrogen dioxide (10102-44-0) → sodium nitrate (7631-99-4) + sodium nitrite (7632-00-0)

Conditions	Yield
oxidation;
oxidation;

sodium azide + oxygen → sodium nitrite (7632-00-0)

Conditions	Yield
With sodium In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;;
With Na In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;;

sodium azide + Nitryl chloride → sodium nitrite (7632-00-0)

sodium azide + barium peroxide (1304-29-6) → sodium nitrite (7632-00-0)

Conditions	Yield
With sodium In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;;
With Na In neat (no solvent) byproducts: N2; oxydation when heating in presence of Na;;

sodium amide + nitrosylchloride (2696-92-6) → sodium nitrite (7632-00-0)

Conditions	Yield
In neat (no solvent)
In neat (no solvent)

sodium sulfide + sodium nitrate (7631-99-4) + sulfur dioxide (7446-09-5) → sodium nitrite (7632-00-0)

Conditions	Yield
In melt byproducts: Na2SO4, Na2SO3; in melt at 330°C;

sodium nitrate (7631-99-4) + hydrogen cation → ammonia (7664-41-7) + hydrogen (1333-74-0) + sodium nitrite (7632-00-0)

Conditions	Yield
In water byproducts: H2O; Electrolysis; electrolysis (1.25V vs. SCE), (Bu4N)4(MoFe3S4(SC6H5)3(O2C6Cl4))2 modified glassy carbon electrode, pH 10;

sodium nitrate (7631-99-4) + nitric acid (7697-37-2) → sodium nitrite (7632-00-0)

Conditions	Yield
In acetic acid Kinetics; other Radiation; γ-ray radiation of (60)Co; at 23°C; dose rate of 1.2 Gy s**(-1);

ammonium nitrate + sodium (7440-23-5) → sodium hyponitrite + disodium nitrite + sodium hydroxide (1310-73-2) + sodium nitrite (7632-00-0)

Conditions	Yield
In ammonia
In ammonia NH3 (liquid);

Iron(III) nitrate nonahydrate + sodium (7440-23-5) → hydrogen (1333-74-0) + iron (7439-89-6) + sodium amide + sodium hydroxide (1310-73-2) + sodium nitrite (7632-00-0)

Conditions	Yield
In ammonia -33°C;
In ammonia NH3 (liquid); -33°C;

nitrogen(II) oxide (10102-43-9) + sodium (7440-23-5) → sodium hyponitrite + sodium nitrite (7632-00-0)

Conditions	Yield
above 190°C;
above 190°C;

nitrogen(II) oxide (10102-43-9) + sodium (7440-23-5) → sodium nitrate (7631-99-4) + sodium nitrite (7632-00-0)

Conditions	Yield
heating with dry NO;

oxygen (80937-33-3) + sodium (7440-23-5) → sodium hydroxide (1310-73-2) + sodium nitrite (7632-00-0)

Conditions	Yield
In ammonia slow O2 flow;
In ammonia NH3 (liquid); slow O2 flow;

sodium nitrate (7631-99-4) + sodium (7440-23-5) → sodium nitrite (7632-00-0)

Conditions	Yield
In ammonia molar ratio of Na:NaNO3 = 2:1;
In ammonia NH3 (liquid); molar ratio of Na:NaNO3 = 2:1;

sodium (7440-23-5) + Nitrogen dioxide (10102-44-0) → sodium nitrite (7632-00-0)

Conditions	Yield
at 22-105°C; pressure of NO2 less then 600 torr;
at 22-105°C; pressure of NO2 less then 600 torr;

sodium (7440-23-5) + Nitrogen dioxide (10102-44-0) → sodium nitrate (7631-99-4) + sodium nitrite (7632-00-0)

Conditions	Yield
burning of Na in NO2 atmosphere;
slow oxidation of Na at the surface, above the melting point;
slow oxidation of Na at the surface, above the melting point;
burning of Na in NO2 atmosphere;

ammonia (7664-41-7) + sodium carbonate (497-19-8) + oxygen → sodium nitrite (7632-00-0)

Conditions	Yield
In neat (no solvent) 2 volumeparts NH3 are combusted with 3 volumeparts O2; formed N2O3 (NO and NO2) is absorped by Na2CO3;;
In neat (no solvent) 2 volumeparts NH3 are combusted with 3 volumeparts O2; formed N2O3 (NO and NO2) is absorped by Na2CO3;;

Nitryl chloride + sodium hydroxide (1310-73-2) → sodium nitrite (7632-00-0)

dinitrogen trioxide (10544-73-7) → sodium nitrite (7632-00-0)

Conditions	Yield
With sodium hydroxide In water byproducts: H2O; absorption of nitrosic gases in alkaline soln.;
With NaOH In water byproducts: H2O; absorption of nitrosic gases in alkaline soln.;

potassium nitrate + sodium hydroxide (1310-73-2) → sodium nitrite (7632-00-0)

Conditions	Yield
With cast iron In melt melting of 500 kg KNO3 and 500 kg NaOH together; reaction of the melt with finely powdered cast iron for 5-6 h;;

sodium nitrite (7632-00-0) → nitrogen(II) oxide (10102-43-9)

Conditions	Yield
With acetic acid; potassium iodide In water Product distribution / selectivity;	100%
With sulfuric acid; water at 10℃; under 375.038 Torr; for 1.38889E-05h; Reagent/catalyst; Temperature; Pressure; Time;	99.99%
With maleic acid; ascorbic acid In water Product distribution / selectivity;

sulfur (7704-34-9) + sodium nitrite (7632-00-0) → sodium thiosulfate

Conditions	Yield
In N,N-dimethyl-formamide byproducts: N2O; at about 80°C, under N2 or CO2, cooling, separation of Na2S2O3;; washing with acetone, analytically pure;;	100%
In further solvent(s) byproducts: N2O; solvent: dimethyl acetamide, at about 80°C, under N2 or CO2, cooling, separation of Na2S2O3;; washing with acetone, analytically pure;;	100%

fac-triaquotrinitroiridium(III) + sodium nitrite (7632-00-0) → trisodium hexanitroiridate(III)

Conditions	Yield
In not given 100°C, 1 h;	100%

+ sodium nitrite (7632-00-0) → αβ-s-{Co(2-methyl-3,6,9-triazaundec-2-ene-1,11-diamine)NO2}(ZnCl4) (117229-37-5)

Conditions	Yield
With ZnCl2 In hydrogenchloride soln. of Co-complex in HCl added NaNO2, heated for 20 min; soln. poured into 2-propanol/acetone (contained ZnCl2), cooled, powder collected, washed (acetone, Et2O), elem. anal.;	100%

αβ-i-{Co(3,6,9-triazaundec-2-ene-1,11-diamine)Cl}(ClO4)2 (117229-25-1) + sodium nitrite (7632-00-0) → αβ-i-{Co(3,6,9-triazaundec-2-ene-1,11-diamine)NO2}(ZnCl4) (117229-27-3)

Conditions	Yield
With ZnCl2 In perchloric acid soln. of Co-complex in HClO4 added NaNO2, heated for 20 min, poured into a acetone/2-propanol mixture with ZnCl2; cooled to 0°C, washed (acetone Et2O), elem. anal.;	100%

tetrakis(methylisocyanide) boron triflate + sodium carbonate (497-19-8) + sodium nitrite (7632-00-0) → 3Na(1+)*(B(CO2)2(CO2H)2)(3-)*2H2O=Na3(B(CO2)2(CO2H)2)*2H2O

Conditions	Yield
In ethanol; sulfuric acid; water aq. H2SO4; B(CNCH3)4(CF3SO3)3 dissolved in H2O and cooled to 0°C, addn. of aq. mixt. of NO and NO2 prepd. from NaNO2, H2SO4, and H2O over 4 h, stirred for 16 h at room temp., addn. of Na2CO3 and ethanol; pptn., filtered, dissolved (H2O), soln. saturated with CO2, addn. of ethanol, pptn., filtered, washed (ethanol, diethyl ether);	100%

[N,N'-bis(2-methyl-2-amino-κN-propyl)oxamidato-κ(2)N,N']copper(II) (252258-61-0) + copper(II) nitrate + sodium nitrite (7632-00-0) → catena-poly[copper(II)-μ-[N,N'-bis(2-methyl-2-aminopropyl)oxamido(2-)-N,N',O':N'',N''',O]copper(II)-di-μ-nitrito(-)-O] (252258-63-2)

Conditions	Yield
In methanol; water addn. of aq. Cu(NO3)2 and then aq. NaNO2 to Cu-complex (in MeOH) with stirring (pptn.); collection (filtration), washing (MeOH, Et2O), drying in air; elem. anal.;	98%

tetrafluoroboric acid + 2,6-dimethoxyaniline (2734-70-5) + sodium nitrite (7632-00-0) → 2,6-dimethoxybenzenediazonium tetrafluoroborate

Conditions	Yield
In water at 0℃; for 0.75h;	98%

tetrafluoroboric acid + 3,4,5-Trimethoxyaniline (24313-88-0) + sodium nitrite (7632-00-0) → 3,4,5-trimethoxybenzenediazonium tetrafluoroborate

Conditions	Yield
In water at 0℃; for 0.5h;	98%
Stage #1: tetrafluoroboric acid; 3,4,5-Trimethoxyaniline In water at 0℃; for 0.25h; Stage #2: sodium nitrite In water at 0℃; for 0.5h;

copper(II) perchlorate hexahydrate + 3,3'-Diamino-N-methyldipropylamine (105-83-9) + sodium nitrite (7632-00-0) → [Cu(3,3'-diamino-N-methyldipropylamine)(ONO)(H2O)]ClO4 (890850-35-8)

Conditions	Yield
In methanol soln. of Cu salt added to soln. of org. compd., hot soln. of NaNO2 addeddropwise, heated for 10 min; hot filtered, allowed to crystallize at room temp., filtered, washed with ether, air-dried; elem. anal.;	97%

(2-aza-5,10,15,20-tetraphenyl-21-carbaporphyrinato)FeBr + sodium nitrite (7632-00-0) → [Fe(CTPP)NO]

Conditions	Yield
1 equiv of NaNO2 under inert atm. at ambient temp.; silica gel column chromy. in a room atm.;	97%

zinc perchlorate + 6,16,2,5-tribenzena(1,4)-1,4,8,11,14,18,23,27-octaazabicyclo[9.9.9]nonacosaphane (119142-71-1) + sodium nitrite (7632-00-0) → [pCZn2(μ-ONO)](ClO4)3

Conditions	Yield
Stage #1: zinc perchlorate; 6,16,2,5-tribenzena(1,4)-1,4,8,11,14,18,23,27-octaazabicyclo[9.9.9]nonacosaphane In methanol at 20℃; for 0.5h; Stage #2: sodium nitrite In methanol for 12h;	97%

[Ru(N,N-dimethyl-4,6-di(pyridin-2-yl)-1,3,5-triazin-2-amine)(2,2'-bipyridine)(CH3CN)](ClO4)2 + sodium nitrite (7632-00-0) → [Ru(N,N-dimethyl-4,6-di(pyridin-2-yl)-1,3,5-triazin-2-amine)(2,2'-bipyridine)(NO2)](ClO4)

Conditions	Yield
In water; acetone for 12h; Reflux; Inert atmosphere;	96.89%

[Ru(η2-C6HCPhCH-1-O-2-CHNHEt-3-NO2-4-Me-5)(PPh3)2(CO)Cl] (350832-46-1) + sodium nitrite (7632-00-0) → [Ru(η2-C6HCPhCH-1-O-2-CHNHEt-3-NO2-4-Me-5)(PPh3)2(CO)(NO2)]

Conditions	Yield
In dichloromethane; water; acetone aq. soln. of NaNO2 added dropwise to Ru complex soln. in CH2Cl2/acetone,stirred for 5 h; solvent removed (vac.), filtered, washed (H2O), dried (vac.); elem. anal.;	96%

tetrafluoroboric acid + sulfamethizole (144-82-1) + sodium nitrite (7632-00-0) → C9H8N5O2S2(1+)*BF4(1-)

Conditions	Yield
In water at 0℃; for 0.75h; Inert atmosphere;	96%

hydrogenchloride (7647-01-0) + ruthenium trichloride + sodium nitrite (7632-00-0) → ruthenium(II)nitrosyl trichloride

Conditions	Yield
In water for 4h; Heating / reflux;	95%

C6F5Ni(P(CH3)2C6H5)2Br + sodium nitrite (7632-00-0) → C6F5Ni(P(CH3)2C6H5)2NO2

Conditions	Yield
In water; acetone prepn. from C6F5Ni(CH3)2C6H5)2Br and excess of NaNO2 in aq. acetone under reflux;;	95%
In water; acetone prepn. from C6F5Ni(CH3)2C6H5)2Br and excess of NaNO2 in aq. acetone under reflux;;	95%

Upstream product

• 96088-55-0 N,N-bis(methylsulfonyl)hydroxylamine 
• 1310-73-2 sodium hydroxide 
• 10102-44-0 Nitrogen dioxide 
• 16824-89-8 N-oxo-N-nitrosoamine 
• 2696-92-6 nitrosylchloride 
• 1313-82-2 sodium sulfide 
• 7631-99-4 sodium nitrate 
• 7446-09-5 sulfur dioxide 
• 7440-23-5 sodium 
• 10102-43-9 nitrogen(II) oxide 
• 80937-33-3 oxygen 
• 7664-41-7 ammonia 
• 497-19-8 sodium carbonate 
• 13444-90-1 Nitryl chloride 

Downstream Products

• 700811-29-6 (2-chloropyridin-4-yl)hydrazine 
• 4758-64-9 ethyl 3,5-dimethyl-4-propylpyrrole-2-carboxylate 
• 109-95-5 ethyl nitrite 
• 7758-09-0 potassium nitrite 
• 10024-97-2 dinitrogen monoxide 
• 7727-37-9 nitrogen 
• 10102-44-0 Nitrogen dioxide 
• 7732-18-5 water 
• 7757-82-6 sodium sulfate 
• 10102-43-9 nitrogen(II) oxide 
• 7681-82-5 sodium iodide 
• 1310-73-2 sodium hydroxide 
• 7664-41-7 ammonia 
• 7803-49-8 hydroxylamine 

Relevant articles and documents

Cu-Pd bimetallic cluster/AC as a novel catalyst for the reduction of nitrate to nitrite

Cu-Pd/AC catalysts that are derived from Cu-Pd clusters were shown to possess high activity for the reduction of nitrate to nitrite, but were inactive for the reduction of nitrite. In contrast, the Pd/AC catalyst was inactive for the reduction of nitrate, whereas conventional Cu-Pd/AC afforded various products, including nitrite, nitrogen, and ammonia.

Radiolysis products of nitrate-acetate aqueous solutions and their influence on pH of the solutions

The influence of the components of nitrate-acetate aqueous solution and products of their radiolysis on pH of the solutions was experimentally studied in a wide dose range. The results can be used to estimate the speciation and migration conditions of radionuclides in a reservoir bed of underground disposed sites of liquid radioactive waste. 2005 Pleiades Publishing, Inc.

Process for producing saleable liquids from organic material

A process for producing saleable liquids from organic material comprising the following steps. Providing organic material and separating it into solids, liquids and vapour. Reacting the liquids, combining it with water vapour and producing a volatized gas stream. Removing nitrogen dioxide from the gas stream to produce a scrubbed volatized gas stream. Reacting the scrubbed volatized gas stream with water vapour to produce a combined volatized gas stream. Removing carbon dioxide from the combined volatized gas stream to produce a subtracted volatized gas stream. Reacting the subtracted volatized gas stream with methanol to produce an enhanced volatized gas stream. Distilling the enhanced volatized gas stream to produce ethanol.