123845-83-0

Upstream product

• 1022-46-4 2-phenyl-4H-3,1-benzoxazin-4-one 
• 65-85-0 benzoic acid 
• 67090-21-5 3-(2-hydroxyethyl)-2-phenyl-quinazoline-(3H)-4-one 

Downstream Products

• 875557-22-5 3-[2-(4-Oxo-2-phenyl-4H-quinazolin-3-yl)-ethyl]-benzoic acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 875557-16-7 3-[2-(4-oxo-2-phenyl-4H-quinazolin-3-yl)-ethyl]-benzoic acid hydrazide 

Relevant academic research and scientific papers

Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones

Amido/imido alcohol/2-phenyl-3-hydroxyethylquinazolin-4 (3H) -one 1 on treatment with benzoic acid in the presence of cone. H2SO4 yields m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxoquinazolinyl) benzoic acids 2. The acid chloride of 2 on reaction with hydrazine hydrate affords m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazides 4 which on condensation with an aromatic aldehyde in acetic acid gives m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo- quinazolinyl) benzoic acid hydrazones 5. Compounds 5 undergo cyclization with phenoxy acetic acid in the presence of thionyl chloride in dry benzene to furnish 1-[m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl- benzamido)]-3-phenoxy-4-phenyl-2-azetidinones 6. The antiviral and antifungal activities of 6 have been reported.