123848-41-9

Upstream product

• 447-31-4 Desyl chloride 
• 451-40-1 phenyl benzyl ketone 
• 108-41-8 1-chloro-3-methylbenzene 
• 99-08-1 1-methyl-3-nitrobenzene 
• 52056-23-2 2-hydroxy-1,2-diphenyl-2-m-tolyl-ethanone 
• 625-95-6 3-Iodotoluene 
• 7664-93-9 sulfuric acid 
• 110247-83-1 (1RS,2RS)-1,2-diphenyl-1-m-tolyl-ethane-1,2-diol 
• 110247-83-1 1,2-Diphenyl-1-m-tolyl-ethane-1,2-diol 
• 110248-47-0 1,1-diphenyl-2-m-tolyl-ethane-1,2-diol 
• 26926-53-4 2-phenyl-2-(m-tolyl)acetonitrile 

Relevant academic research and scientific papers

Method for preparing alpha-aryl ketone compound by using palladium complex

The invention relates to a method for preparing an alpha-aryl ketone compound by using a palladium complex, which comprises the steps of in the presence of alkali, taking ketone and halogenated hydrocarbon as raw materials, taking the palladium complex containing an ortho-carborane benzothiazole structure as a catalyst, and carrying out alpha-halogenation reaction at room temperature to prepare the alpha-aryl ketone compound. Compared with the prior art, the palladium complex containing the ortho-carborane benzothiazole structure is applied to catalysis of the alpha-halogenation reaction of ketone and halogenated hydrocarbon, the alpha-aryl substituted ketone compound is prepared through a one-pot method, synthesis of the alpha-aryl ketone compound at room temperature by using simple, easily available and cheap raw materials is achieved, and the method has the advantages of low catalyst use equivalent, mild reaction conditions, more catalytic substrates, high substrate universality and high yield.

Palladium-catalyzed denitrative α-arylation of ketones with nitroarenes

The palladium-catalyzed α-arylation of ketones with readily available nitroarenes and nitroheteroarenes provides access to useful α-aryl and α-heteroaryl ketones. The use of the Pd/ BrettPhos catalysts was critical to achieve high efficiency for these transformations, whereas other catalysts led to decreased yields or no conversions. The intramolecular type substrate was also applied in this methodology and gave a chromone derivative. Polyaromatic carbonyl compounds can be easily obtained by multicomponent tandem reactions, via nucleophilic aromatic substitution (SNAr) or cross-coupling reaction followed by this denitrative arylation. Kinetic experiments show that the electronic effect of nitrobenzenes has a greater effect on the reaction rate than the electronic effect of ketones.

Metal Free, Direct and Selective Deoxygenation of α-Hydroxy Carbonyl Compounds: Access to α,α-Diaryl Carbonyl Compounds

An efficient, metal free, direct and selective deoxygenation of α-hydroxy carbonyl compounds is achieved with the aid of catalytic amount of aqueous HClO4 (70 %) and triethylsilane as hydride source. A variety of α-hydroxy-α,α-diaryl carbonyl compounds are selectively deoxygenated to give α,α-diaryl carbonyl compounds in good to excellent yields. Intermediacy of α-keto carbenium ion is proposed on the basis of some control experiments and atmospheric pressure chemical ionization mass spectral analysis.

Aqueous α-Arylation of Mono- and Diarylethanone Enolates at Low Catalyst Loading

Acetophenone and deoxybenzoin derivatives are selectively α-arylated using a combination of very small amounts of palladium acetate and diphenylphosphine oxide as catalyst system and water as the only solvent. Target di- and triarylethanones are isolated virtually free of metal residues, and the reaction is amenable to gram-scale. A mechanistic proposal based on TEM images, poisoning experiments, kinetic plot and ESI-MS spectrometry is also provided. (Figure presented.).

PROCESS FOR CREATING CARBON-CARBON BONDS USING CARBONYL COMPOUNDS

The present invention concerns a process for preparing a compound of formula (I) by reaction between a compound of formula (II) and a compound of formula (III) in the presence of a copper-containing catalyst, a ligand and base. The invention also concerns the implementing of this process for the preparation of building blocks to prepare molecules of interest in particular in the pharmaceutical, agro-chemical fields, etc.

Direct copper-catalyzed α-arylation of benzyl phenyl ketones with aryl iodides: Route towards tamoxifen

No activation needed: The first efficient method for direct α-arylation of non-activated or non-protected family of enolizable ketones with simple aryl iodides employs a catalytic copper system. The method shows potential for the easy and step-economical synthesis of tamoxifen, the most commonly administrated drug for the management of breast cancer. R, R′, R′′ = electron-donating or electron-withdrawing groups. Copyright

Pinacol Rearrangement in the Solid State

The pinacol rearrangement in the solid state was found to proceed faster and more selectively than that in solution.A highly selective rearrangement was observed in the reaction of pinacol in its host-guest complex in the solid state.