1238593-23-1

Basic information

• Product Name: (R)-N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrogensulfate
• Synonyms: (R)-N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrogensulfate
• CAS NO: 1238593-23-1
• Molecular Weight: 377.933
• Mol File: 1238593-23-1.mol

Chemical Properties

• CAS DataBase Reference: (R)-N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrogensulfate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrogensulfate(1238593-23-1)
• EPA Substance Registry System: (R)-N,N-dimethyl-1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutylamine hydrogensulfate(1238593-23-1)

Safety Data

• Hazardous Substances Data: 1238593-23-1(Hazardous Substances Data)

Upstream product

• 106650-56-0 sibutramine 

Relevant articles and documents

(Ｒ)-SIBUTRAMINE SALTS AND THE PREPARATION THEREOF

The present invention provides novel anhydrous crystalline (R)-sibutramine salts. Further, the present invention provides an optical resolution method of racemic sibutramine using optically active tartaric acid as an optical resolution agent, a method of preparing (R)-sibutramine salts using the same, and a racemization method of (S)-sibutramine. The anhydrous crystalline (R)-sibutramine hydrogen sulfate of the present invention is useful as an active ingredient of pharmaceutical compositions, due to having significantly high water solubility and excellent stability against moisture and high temperatures, as compared to the conventional (R,S)-sibutramine hydrochloride monohydrate. Further, the preparation method of the present invention is convenient and economic from a process point of view.