1238644-23-9Relevant academic research and scientific papers
A nimesulide derivative with potential anti-inflammatory activity: Synthesis, X-ray powder structure analysis and DFT study
Bhattacharya, Abir,Kankanala, Kavitha,Pal, Sarbani,Mukherjee, Alok K.
, p. 40 - 46 (2010)
A nimesulide derivative, N-[4-(2,5-dioxo-2,5-dihydropyrrol-1-yl)-2-phenoxyphenyl]methanesulfonamide (2), was synthesized and its crystal structure has been determined from X-ray powder diffraction data following direct-space global optimization technique and refined by the Rietveld method. The molecular geometry and electronic structure of the title compound were calculated at the DFT level using the hybrid exchange-correlation functional, BLYP. The optimized molecular geometry of 2 corresponds closely to that obtained from the X-ray structure analysis. Intermolecular N-H···O and C-H···O hydrogen bonds in 2 form one-dimensional polymeric chains of R22(8) rings propagating along the [1 0 0] direction. Further linking between parallel chains via C-H···π (arene) hydrogen bonds generates a two-dimensional supramolecular assembly in the (1 1 0) plane. The title compound exhibits potential anti-inflammatory activity and can induce 64% edema inhibition in rat paws.
Synthesis of nimesulide based new class of succinimide analogues: Their evaluation as potential cytotoxic agents
Kankanala, Kavitha,Mukkanti, Khagga,Pal, Sarbani,Reddy, Vangala Ranga,Devi, Yumnam Priyadarshini,Mangamoori, Lakshmi Narasu
, p. 742 - 748,7 (2020/09/15)
Novel succinimide derivatives based on nimesulide were designed as potential anticancer agents and their synthesis was carried out using a straightforward and atom economic method. The key step of this methodology involved an Aza-Michael addition of several nitrogen nucleophiles to the corresponding N-aryl maleimide derivatives prepared efficiently from nimesulide via a two-step process. A number of compounds containing-NHX (X = Ar, NHCOR, NHAr etc) at the C-3 of the succinimide were prepared in good yields. A number of compounds synthesized were tested for their cytotoxicity in vitro against human colon cancer cell lines and some of them showed promising activities.
Lewis acid free high speed synthesis of nimesulide-based novel N-substituted cyclic imides
Kankanala, Kavitha,Reddy, Vangala Ranga,Mukkanti, Khagga,Pal, Sarbani
experimental part, p. 1060 - 1064 (2010/10/04)
The frst synthesis of nimesulide-based novel cyclic imides has been accomplished via the reaction of an amine prepared from nimesulide with appropriate anhydrides in the presence of sodium acetate. Using this process a variety of N-substituted cyclic imides was prepared in good yields in glacial acetic acid. Some of the compounds synthesized showed anti-infammatory activities when tested in vivo.
