1403656-22-3Relevant academic research and scientific papers
Synthesis of nimesulide based new class of succinimide analogues: Their evaluation as potential cytotoxic agents
Kankanala, Kavitha,Mukkanti, Khagga,Pal, Sarbani,Reddy, Vangala Ranga,Devi, Yumnam Priyadarshini,Mangamoori, Lakshmi Narasu
, p. 742 - 748,7 (2020/09/15)
Novel succinimide derivatives based on nimesulide were designed as potential anticancer agents and their synthesis was carried out using a straightforward and atom economic method. The key step of this methodology involved an Aza-Michael addition of several nitrogen nucleophiles to the corresponding N-aryl maleimide derivatives prepared efficiently from nimesulide via a two-step process. A number of compounds containing-NHX (X = Ar, NHCOR, NHAr etc) at the C-3 of the succinimide were prepared in good yields. A number of compounds synthesized were tested for their cytotoxicity in vitro against human colon cancer cell lines and some of them showed promising activities.
