1238702-58-3

Usage

Uses

Used in Organic Synthesis:
1-Phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is used as a reagent for carbon-carbon bond formation in organic synthesis. Its tetramethyl dioxaborolane moiety and phenyl group enhance its reactivity, making it suitable for various coupling reactions.
Used in Suzuki-Miyaura Cross-Coupling Reactions:
In the field of organic synthesis, 1-Phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is used as a reagent in Suzuki-Miyaura cross-coupling reactions. This palladium-catalyzed reaction allows for the formation of carbon-carbon bonds between aryl or vinyl halides and boronic acids or esters, enabling the synthesis of various organic compounds.
Used as a Ligand in Catalytic Processes:
1-Phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole also serves as a ligand in catalytic processes. Its unique structure and reactivity make it a valuable component in the development of catalysts for various chemical transformations, improving the efficiency and selectivity of these reactions.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1-Phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is used as a building block for the synthesis of bioactive compounds. Its versatile chemical properties and reactivity make it a valuable component in the development of new drugs and pharmaceutical agents.
Used in Material Science:
1-Phenyl-5-(4,4,5,5-tetraMethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole is also utilized in material science for the synthesis of advanced materials with specific properties. Its reactivity and ability to form stable bonds make it suitable for the development of new materials with applications in various fields, such as electronics, energy storage, and nanotechnology.

Upstream product

• 76-09-5 2,3-dimethyl-2,3-butane diol 
• 1238702-56-1 (1-phenyl-1H-pyrazol-5-yl)boronic acid 
• 1126-00-7 1-phenylpyrazole 

Downstream Products

• 1238696-33-7 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-quinolin-8-ylpyridazin-4(1H)-one 
• 1238696-55-3 5-Methoxy-1-(2,2,3,3,7-pentafluoro-2,3-dihydro-1,4-benzodioxin-6-yl)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357192-31-4 1-benzyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357192-32-5 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol 
• 1357590-67-0 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-(1,2,3,4-tetrahydronaphthalen-2-yl)pyridazin-4(1H)-one 
• 1357590-79-4 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-(phenylsulfonyl)pyridazin-4(1H)-one 
• 1357590-85-2 1-(biphenyl-3-ylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357591-77-5 1-[1-(diphenylmethyl)azetidin-3-yl]-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357591-80-0 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-[2-(trifluoromethyl)benzyl]pyridazin-4(1H)-one 
• 1357592-87-0 1-cyclopropyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357358-24-7 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)-1-(2,2,2-trifluoroethyl)pyridazin-4(1H)-one 
• 1357589-17-3 5-(1-phenyl-1H-pyrazol-5-yl)-1-[3-(trifluoromethyl)phenyl]pyridazin-4(1H)-one 
• 1357358-22-5 1-cyclobutyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357358-23-6 1-cyclobutyl-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 

Relevant academic research and scientific papers

IMIDAZOPYRIDINE DERIVATIVES

The present invention relates to compounds of general formula (I) wherein Ar is phenyl or pyridinyl; X1 is N or CH, X2 is N or CH, with the proviso that only one of X1 or X2 is N and the other is CH; R1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, cyano or S(O)2-lower alkyl; R2 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen or cyano; n is 1 or 2; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds may be used for the treatment of schizophrenia, obsessive-compulsive personality disorder, major depression, bipolar disorders, anxiety disorders, normal aging, epilepsy, retinal degeneration, traumatic brain injury, spinal cord injury, post-traumatic stress disorder, panic disorder, Parkinson's disease, dementia, Alzheimer's disease, mild cognitive impairment, chemotherapy-induced cognitive dysfunction, Down syndrome, autism spectrum disorders, hearing loss, tinnitus, spinocerebellar ataxia, amyotrophic lateral sclerosis, multiple sclerosis, Huntington's disease, stroke, radiation therapy, chronic stress, abuse of neuro-active drugs, such as alcohol, opiates, methamphetamine, phencyclidine and cocaine.

HETEROCYCLIC COMPOUND

The present invention provides a compound represented by the formula (1): wherein each symbol is as defined in the specification, or a salt thereof, a prodrug of the compound or a salt thereof, a medicament containing the compound or a salt thereof, the medicament which is a phosphodiesterase 10A inhibitor, and a medicament which is for preventing or treating schizophrenia.

FUSED HETEROCYCLIC RING COMPOUND

Provided is a compound having a PDE10A inhibitory action, and useful as a medicament for the prophylaxis or treatment of mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.

HETEROCYCLIC COMPOUND AND USE THEREOF

The present invention aims to provide a compound having a PDE inhibitory action and useful as a medicament for the prophylaxis or treatment of schizophrenia and the like. A compound represented by the formula (1x): wherein each symbol is as des

Pyridazinone compounds

The present invention provides a compound which has the effect of PDE inhibition, and which is useful as a medicament for preventing or treating schizophrenia or so on. A compound of formula (I0): wherein R1 represents a substituent, R2 represents a hydrogen atom, or a substituent, R3 represents a hydrogen atom, or a substituent, Ring A represents an aromatic ring which can be substituted, and Ring B represents a 5-membered heteroaromatic ring which can be substituted, or a salt thereof.