1357358-05-4

Basic information

• Product Name: 1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
• Synonyms: 1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one
• CAS NO: 1357358-05-4
• Molecular Weight: 322.367
• Mol File: 1357358-05-4.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one(1357358-05-4)
• EPA Substance Registry System: 1-(cyclopropylmethyl)-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one(1357358-05-4)

Safety Data

• Hazardous Substances Data: 1357358-05-4(Hazardous Substances Data)

Upstream product

• 111335-53-6 3-chloro-5-methoxy-4(1H)-pyridazinone 
• 1238702-58-3 1-phenyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-pyrazole 
• 1357590-75-0 3-chloro-1-(cyclopropylmethyl)-5-methoxypyridazin-4(1H)-one 
• 1357192-32-5 5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4-ol 
• 7051-34-5 cyclopropylcarbinyl bromide 
• 1357192-31-4 1-benzyl-5-methoxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357192-30-3 1-benzyl-3-chloro-5-methoxypyridazin-4(1H)-one 
• 2096-22-2 3-chloro-4,5-dimethoxypyridazine 
• 1238702-56-1 (1-phenyl-1H-pyrazol-5-yl)boronic acid 
• 1126-00-7 1-phenylpyrazole 

Downstream Products

• 1357358-06-5 1-(cyclopropylmethyl)-5-hydroxy-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357357-76-6 1-(cyclopropylmethyl)-5-[3-(1-methyl-1H-benzimidazol-2-yl)propoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357357-77-7 1-(cyclopropylmethyl)-5-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethoxy]-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 
• 1357357-87-9 1-(cyclopropylmethyl)-5-(2-((1-methyl-1H-benzimidazol-2-yl)oxy)ethoxy)-3-(1-phenyl-1H-pyrazol-5-yl)pyridazin-4(1H)-one 

Relevant articles and documents

Design and synthesis of potent and selective pyridazin-4(1H)-one-based PDE10A inhibitors interacting with Tyr683 in the PDE10A selectivity pocket

Utilizing structure-based drug design techniques, we designed and synthesized phosphodiesterase 10A (PDE10A) inhibitors based on pyridazin-4(1H)-one. These compounds can interact with Tyr683 in the PDE10A selectivity pocket. Pyridazin-4(1H)-one derivative

FUSED HETEROCYCLIC RING COMPOUND

Provided is a compound having a PDE10A inhibitory action, and useful as a medicament for the prophylaxis or treatment of mental diseases such as schizophrenia and the like, and the like. A compound represented by the formula (I): wherein each symbol is as defined in the DESCRIPTION, or a salt thereof.