123878-26-2Relevant articles and documents
Ancistrobertsonines B, C, and D as well as 1,2- didehydroancistrobertsonine D from Ancistrocladus robertsoniorum
Bringmann, Gerhard,Teltschik, Friedrich,Michel, Manuela,Busemann, Stefan,Rueckert, Markus,Haller, Rene,Baer, Sabine,Robertson, S. Anne,Kaminsky, Ronald
, p. 321 - 332 (1999)
From the East African Liana Ancistrocladus robertsoniorum, four new naphthylisoquinoline alkaloids have been isolated using High Speed Countercurrent Chromatography (HSCCC) and High Performance Liquid Chromatography (HPLC). Their stereostructures were established by spectroscopic, chemical, and chiroptical methods. Two of the new compounds, ancistrobertsonines B and C, constitute O- and N-permethylated 5,1'-coupled and 5,8'-coupled regioisomeric naphthylisoquinolines, while ancistrobertsonine D and its 1,2-didehydro analogue are based on a 7,1'- coupling mode between the isoquinoline and naphthalene moieties. Biological tests revealed that some of the isolated alkaloids possess moderate antimalarial activities.
Synthetic Approaches to the Naphthyl-isoquinoline Alkaloids. Part 1. Dehydroancistrocladisine
Rizzacasa, Mark A.,Sargent, Melvyn V.
, p. 841 - 844 (2007/10/02)
A synthesis of (+/-)-7-(4,5-dimethoxy-2-methyl-1-naphthyl)-6,8-dimethoxy-1,3-dimethylisoqinoline (dehydroancistrocladisine) 19, the racemic form of a degradation product of the unusual naphthylisoquinoline alkaloid ancistrocladisine 3, is recorded.The key
Synthetic Approaches to the Alkaloids of the Ancistrocladacea: Dehydroancistrocladisine
Rizzacasa, Mark,Sargent, Melvyn V.
, p. 301 - 302 (2007/10/02)
Dehydroancistrocladisine, a derivative of ancistrocladisine which is a member of the unusual naphthyl-isoquinoline group of alkaloids, has been synthesized by a route which can be adapted to provide asymmetric syntheses of thes alkaloids.