1238945-94-2

Upstream product

• 610-94-6 2-bromobenzoic acid methyl ester 
• 196953-04-5 1-(2-bromophenyl)-buta-2,3-dien-1-one 
• 6630-33-7 ortho-bromobenzaldehyde 
• 72454-54-7 4-(2-bromophenyl)but-3-en-2-one 

Downstream Products

• 1446270-83-2 2-methyl-5-phenylpyrazolo[5,1-a]isoquinoline 
• 1427691-30-2 5-(4-bromophenyl)-2-methylpyrazolo[1,5-c]quinazoline 
• 1427691-39-1 (E)-2-methyl-5-styrylpyrazolo[1,5-c]quinazoline 
• 1427691-35-7 5-(3,4-dimethoxyphenyl)-2-methylpyrazolo[1,5-c]quinazoline 
• 1427691-34-6 2-methyl-5-(4-(trifluoromethyl)phenyl)pyrazolo[1,5-c]quinazoline 
• 1427691-33-5 5-(2-chlorophenyl)-2-methylpyrazolo[1,5-c]quinazoline 
• 1427691-32-4 5-(3-chlorophenyl)-2-methylpyrazolo[1,5-c]quinazoline 

Relevant academic research and scientific papers

Monohydrochloride Assisted Synthesis of Functionalized Isoxazoles and Pyrazoles from Allenic Ketones: First Synthesis of (Z)-2-Methyl-7H-benzo[b]pyrazolo[5,1-d][1,5]oxazocines

A facile hydrochloride promoted regioselective synthesis of isoxazoles and pyrazoles from 1,2-allenic ketones is reported. The reaction has been scaled up to gram scale. A direct 8-endo dig ring annulations towards the first synthesis of (Z)-2-methyl-7H-b

Polycyclic compound including nitrogen and organic light emitting device using same

The present invention relates to a polycyclic compound including nitrogen and an organic light emitting device using the same.

Synthesis of Pyrazolo[5,1-a]isoquinolines and 8-Methylenepyrazolo[5,1-a]isoindoles via Regioselective C-C Coupling and Alkyne Hydroamination

An efficient and convenient synthesis of pyrazolo[5,1-a]isoquinolines has been achieved via palladium-catalyzed Sonogashira coupling of terminal alkynes with 5-(2-bromophenyl)-1H-pyrazoles, in situ formed from the condensation of 1-(2-bromophenyl)buta-2,3-dien-1-ones with hydrazine hydrate, followed by 6-endo intramolecular alkyne hydroamination. More interestingly, 8-methylenepyrazolo[5,1-a]isoindoles, the regioisomer of pyrazolo[5,1-a]isoquinolines, could also be selectively synthesized from the same starting materials through an initial intermolecular hydroamination of terminal alkynes with 5-(2-bromophenyl)-1H-pyrazoles followed by a palladium-catalyzed 5-exo intramolecular Heck coupling reaction.

A simple and efficient synthesis of pyrazoles in water

A simple, highly efficient, and environmentally friendly method for the synthesis of substituted 1H-pyrazoles by one-pot condensation reaction of α,β-unsaturated carbonyl compounds with tosyl hydrazide in water was developed. The reaction system exhibited tolerance with various functional groups, Aromatic moiety with both electron-rich and electron-deficient substituents could give desired products in good to excellent yields.