1446270-83-2Relevant academic research and scientific papers
Ruthenium-catalyzed α-carbonyl sulfoxonium ylide annulations with aryl substituted pyrazoles: Via C-H/N-H bond functionalizations
Chen, Tian,Chen, Zhangpei,Ding, Zhiqiang,Meng, Lingxin,Wang, Gongshu
supporting information, p. 8486 - 8490 (2020/11/05)
An efficient method for the construction of various pyrazolo[5,1-a]isoquinolines has been achieved via Ru(ii)-catalyzed α-carbonyl sulfoxonium ylide annulations with aryl substituted pyrazoles. This oxidant-free transformation occurred through pyrazole-directed C-H activation, Ru-carbene insertion, and acid-promoted carbonyl condensation processes, enabling dual C-C and C-N bond formation. A broad substrate scope with respect to both coupling components worked efficiently with high yields. This journal is
Synthesis of Pyrazolo[5,1-a]isoquinolines and 8-Methylenepyrazolo[5,1-a]isoindoles via Regioselective C-C Coupling and Alkyne Hydroamination
Fan, Xuesen,Yan, Meng,Wang, Yuanyuan,Zhang, Xinying
, p. 10536 - 10547 (2015/11/18)
An efficient and convenient synthesis of pyrazolo[5,1-a]isoquinolines has been achieved via palladium-catalyzed Sonogashira coupling of terminal alkynes with 5-(2-bromophenyl)-1H-pyrazoles, in situ formed from the condensation of 1-(2-bromophenyl)buta-2,3-dien-1-ones with hydrazine hydrate, followed by 6-endo intramolecular alkyne hydroamination. More interestingly, 8-methylenepyrazolo[5,1-a]isoindoles, the regioisomer of pyrazolo[5,1-a]isoquinolines, could also be selectively synthesized from the same starting materials through an initial intermolecular hydroamination of terminal alkynes with 5-(2-bromophenyl)-1H-pyrazoles followed by a palladium-catalyzed 5-exo intramolecular Heck coupling reaction.
Palladium-catalyzed oxidation of amine in air: An efficient approach to H-pyrazolo[5,1-a]-isoquinolines
Sheng, Jie,Guo, Ying,Wu, Jie
supporting information, p. 6495 - 6499 (2013/07/26)
An efficient approach to H-pyrazolo[5,1-a]isoquinolines through a reaction of N′-(2-alkynylbenzylidene)hydrazide with amine in the presence of a cooperative catalysis under mild conditions is reported. The palladium-catalyzed oxidation of amine in air lea
