1238951-40-0

Upstream product

• 2398-37-0 3-methoxyphenyl bromide 
• 163765-44-4 (R)-tert-butyl 3-methylpiperazine-1-carboxylate 

Downstream Products

• 1238951-46-6 C₁₁H₁₆N₂O 
• 1435949-60-2 C₃₁H₄₄N₄O₅ 
• 1435949-64-6 C₂₂H₃₅N₃O₄ 
• 1436378-46-9 (3R)-7-hydroxy-N-[(1S)-1-[[(3R)-4-(3-hydroxyphenyl)-3-methylpiperazin-1-yl]methyl]-2-methylpropyl]-1,2,3,4-tetrahydroisoquinoline-3-carboxamide 
• 1445947-58-9 (2R)-4-(3-methoxyphenyl)-3-methylpiperazine 
• 1435949-10-2 {(2R)-4-[(2S)-2-amino-3-methylbutyl]-1-(3-methoxyphenyl)-2-methylpiperazine} 
• 1435949-12-4 3-{(2R)-4-[(2S)-2-amino-3-methylbutyl]-2-methylpiperazine-1-yl}phenol 

Relevant academic research and scientific papers

ANTI-HCMV VIRUS COMPOUND

Disclosed are a class of fused cyclic compounds against the HCMV virus, and use thereof in the preparation of a drugs for treating diseases associated with the HCMV virus. In particular, disclosed is the compound shown in formula (II) and pharmaceutically acceptable salts thereof.

ARYLPIPERAZINE OPIOID RECEPTOR ANTAGONISTS

Provided are opioid receptor antagonists represented by the formula (I) where R, Y3, R1, R2, R3, R4 and R5 are as defined herein.

1-Substituted 4-(3-Hydroxyphenyl)piperazines are pure opioid receptor antagonists

This report describes the discovery that 1-substituted 4-(3-hydroxyphenyl) piperazines are pure opioid receptor antagonists. Compounds in this new series include N-phenylpropyl (3S)-3-methyl-4-(3-hydroxyphenyl)piperazine and (3R)-3-methyl-4-(3-hydroxyphenyl)piperazine, both of which display low nanomolar potencies at μ, δ, and κ receptors and pure antagonist properties in a [35S]GTPγS assay.