1239059-72-3Relevant academic research and scientific papers
Iron-catalyzed Michael reactions revisited: A synthetically useful process for the preparation of tri-carbonyl compounds and chiral warfarin
Yang, Hua-Meng,Gao, Yue-Hua,Li, Li,Jiang, Zhen-Yu,Lai, Guo-Qiao,Xia, Chun-Gu,Xu, Li-Wen
, p. 3836 - 3839 (2010)
The LBAs (Lewis acid-assisted Br?nsted acid catalysis) is proposed as possible mechanistic process in the simple FeCl3-catalyzed Michael reactions of chalcones with active methylene compounds in organic solvents. And iron salts were found to be effective promoters in the asymmetric Michael addition of 4-hydroxycoumarin to α,β-unsaturated ketone, which resulted in excellent yield and high level of enantioselectivity (up to 91% ee) in the presence of low catalytic amount of iron and simple chiral primary amine.
