1239085-70-1

Basic information

• Product Name: 2-(2-ethynylphenyl)-1-phenylethan-1-ol
• Synonyms: 2-(2-ethynylphenyl)-1-phenylethan-1-ol
• CAS NO: 1239085-70-1
• Molecular Weight: 222.287
• Mol File: 1239085-70-1.mol

Chemical Properties

• CAS DataBase Reference: 2-(2-ethynylphenyl)-1-phenylethan-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-ethynylphenyl)-1-phenylethan-1-ol(1239085-70-1)
• EPA Substance Registry System: 2-(2-ethynylphenyl)-1-phenylethan-1-ol(1239085-70-1)

Safety Data

• Hazardous Substances Data: 1239085-70-1(Hazardous Substances Data)

Upstream product

• 583-55-1 1-Bromo-2-iodobenzene 
• 96-09-3 styrene oxide 
• 38274-16-7 2-bromo-1-(trimethylsilylethynyl)benzene 
• 109347-41-3 2-(2-iodophenyl)acetaldehyde 
• 100-59-4 phenylmagnesium chloride 
• 117269-57-5 2-(2-iodophenyl)-1-phenylethan-1-ol 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 1239085-86-9 2-phenyl-1,2-dihydrobenzo[d]oxepine 

Relevant articles and documents

Efficient endo Cycloisomerization of Terminal Alkynols Catalyzed by a New Ruthenium Complex with 8-(Diphenylphosphino)quinoline Ligand and Mechanistic Investigation

Several new ruthenium complexes supported by the P,N-donor ligand 8-(diphenylphosphino)quinoline (DPPQ) were synthesized, including [RuCl2(DPPQ)2] (1), [Ru(μ-Cl)(DPPQ)2]2(BPh4)2 (2), and [RuCl(DPPQ)2Py](BF4) (3). Complex 2, with only 1 mol % loading, was found to be catalytically active for the endo cycloisomerization of various terminal alkynols to endo-cyclic enol ethers in moderate to excellent yields. In particular, the 7- and 8-endo heterocyclization can be achieved efficiently to give the seven-membered 3-benzoxepine and eight-membered 3-benzo[d]oxocine derivatives. The stoichiometric reactions of 2 with various alkynol substrates have been carried out to investigate the mechanism, which led to a series of seven-, six-, and five-membered oxacyclocarbene ruthenium complexes including [RuCl(DPPQ)2{=CCH2C6H4CH2CH2O}](BPh4) (12) and [RuCl(DPPQ)2{=CCH2(CH2)nCH2O}](BPh4) (n=3, 12′; n=2, 13; n=1, 14). The quantitative transformation of oxacyclocarbene 12 into catalyst 2 and 3-benzoxepine 5 a as well as the efficient catalytic activity of 12 for the endo-cyclization of 2-(2-ethynylphenyl)ethanol (4 a) demonstrated that 12 is a key intermediate involved in the catalytic cycle. Moreover, comparative studies on the modeling reactions and catalytic activity of the series of oxacyclocarbene complexes indicated that the different catalytic activity of 2 for the endo-cycloisomerization of different types of alkynols can be related to the reactivity of the respective ruthenium oxacyclocarbene intermediates.

1,2,3-Triazoles as inhibitors of indoleamine 2,3-dioxygenase 2 (IDO2)

Indoleamine 2,3-dioxygenase 2 (IDO2) is a potential therapeutic target for the treatment of diseases that involve immune escape such as cancer. In contrast to IDO1, only a very limited number of inhibitors have been described for IDO2 due to inherent diff

Osmium-catalyzed 7-endo heterocyclization of aromatic alkynols into benzoxepines

[Figure Presented] The wizard of Os: Regioselective osmiumcatalyzed 7-endo heterocyclization of aromatic alkynols affords benzoxepines in good yields. The proposed catalytic cycle involves the key formation of osmiumvinylidene complexes via an alkynyl-hydride-osmium(IV) complex from the starting alkynol.