123930-22-3

Upstream product

• 122252-56-6 β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-δ-oxobenzenepentanoic acid, ethyl ester 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 1608-51-1 4-fluorochalcone 
• 122252-70-4 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxylic acid, ethyl ester 
• 122253-00-3 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol 
• 122253-23-0 3-Bromomethyl-4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridine 
• 86030-96-8 (2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-carbaldehyde 
• 122287-13-2 [4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylmethyl]-triphenyl-phosphonium; bromide 

Downstream Products

• 122253-88-7 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-ol 
• 122254-10-8 (4R,6S)-4-(tert-Butyl-diphenyl-silanyloxy)-6-{(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-tetrahydro-pyran-2-one 

Relevant academic research and scientific papers

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)