122252-70-4

Upstream product

• 1608-51-1 4-fluorochalcone 
• 459-57-4 4-fluorobenzaldehyde 
• 98-86-2 acetophenone 
• 7152-15-0 ethyl 4-methyl-3-oxo-pentanoate 
• 122252-56-6 β-(4-fluorophenyl)-α-(2-methyl-1-oxopropyl)-δ-oxobenzenepentanoic acid, ethyl ester 

Downstream Products

• 122253-00-3 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinemethanol 
• 128108-47-4 4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinecarboxaldehyde 
• 129122-55-0 (E)-4-(4-Fluorophenyl)-3-(2-iodoethenyl)-2-(1-methylethyl)-6-phenylpyridin 
• 129122-42-5 3-ethynyl-4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenylpyridine 
• 129122-41-4 1,1-Dibromo-2-(4-(4-fluorophenyl)-2-(1-methylethyl)-6-phenylpyridin-3-yl)ethene 
• 129122-54-9 (S)-4-({2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-ethyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester 
• 129122-45-8 (S)-4-{[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-3-hydroxy-butyric acid methyl ester 
• 129122-57-2 (S)-4-({(E)-2-[4-(4-Fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-3-hydroxy-butyric acid methyl ester 
• 129122-52-7 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-({(E)-2-[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-yl]-vinyl}-methoxy-phosphinoyl)-butyric acid methyl ester 
• 129122-44-7 (S)-3-(tert-Butyl-diphenyl-silanyloxy)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylethynyl]-methoxy-phosphinoyl}-butyric acid methyl ester 
• 129121-94-4 C₂₆H₂₇FNO₅P^(2-)*2Li⁽¹⁺⁾ 
• 135426-58-3 Sodium; (S)-4-{[4-(4-fluoro-phenyl)-2-isopropyl-6-phenyl-pyridin-3-ylmethoxy]-hydroxy-phosphoryl}-3-hydroxy-butyrate 
• 129121-95-5 (S,E)-4-[[2-[4-(4-Fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethenyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, dilithium salt 
• 129137-09-3 (S)-4-[[[4-(4-Fluorophenyl)-2-(1-methylethyl)-6-phenyl-3-pyridinyl]ethynyl]hydroxyphosphinyl]-3-hydroxybutanoic acid, dilithium salt 

Relevant academic research and scientific papers

PYRIDINE ANCHORS FOR HMG-COA REDUCTASE INHIBITORS

Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the e

Phosphorus-Containing Inhibitors of HMG-CoA Reductase. 2. Synthesis and Biological Activites of a Series of Substituted Pyrydynes Containing a Hydroxyphosphinyl Moiety

A series of 2,3,4,(5),6-substituted pyridines containing a hydroxyphosphinyl functionality have been prepared and were evaluated for their ability to inhibit the enzyme HMG-CoA reductase.Systematic substitution of both R1-R4 and X-Y

Synthesis and Biological Activity of New HMG-CoA Reductase Inhibitors. 1. Lactones of Pyridine- and Pyrimidine-Substituted 3,5-Dihydroxy-6-heptenoic (-heptanoic) Acids

Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids 2-4 have been synthesized.Extensive exploration of structure-activity relationships led to several compounds exceeding the inhibitory activity of mevinolin (1b)