1239331-78-2Relevant academic research and scientific papers
A convenient synthesis of 2,3-dihydro-3-methylidene-1H-isoindol-1-ones by reaction of 2-formylbenzonitriles with dimethyloxosulfonium methylide
Kobayashi, Kazuhiro,Matsumoto, Kota,Nakamura, Daizo,Fukamachi, Shuhei,Konishi, Hisatoshi
, p. 1048 - 1051 (2010)
A facile method for the synthesis of 2,3-dihydro-3-methylidene-1H-isoindol- 1-one and its derivatives carrying substituent(s) at C(5) and/or C(6) has been developed. The reaction of 2-formylbenzonitrile (1a) with dimethyloxosulfonium methylide, generated by the treatment of trimethylsulfoxonium iodide with NaH in DMSO/THF at 0°, resulted in the formation of 2,3-dihydro-3-methylidene- 1Hisoindol-1-one (2a) in 77% yield. Similarly, six 2-formylbenzonitriles carrying substituent(s) at C(4) and/ or C(5), i.e., 1b - 1g, also gave the corresponding expected products 2b - 2g in comparable yields.
