1239333-72-2Relevant academic research and scientific papers
Synthetic studies on lactonamycins: Synthesis of the model BCDEF aglycon
Watanabe, Kana,Iwata, Yusuke,Adachi, Satoshi,Nishikawa, Tomoyuki,Yoshida, Yuko,Kameda, Shunsuke,Ide, Mitsuaki,Saikawa, Yoko,Nakata, Masaya
experimental part, p. 5573 - 5579 (2010/11/05)
The lactonamycin model aglycon 4 was synthesized from the trihalogenated benzene derivative 10. Ethynyltetraol 6 was prepared from 10 via carbon elongations, oxidative demethylation, a cycloaddition reaction with the diene derived from homophthalic anhydride, and dihydroxylation. Final E- and F-ring constructions from 6 were realized via a palladium-catalyzed cyclization-methoxycarbonylation, a stereoselective methanol addition, and lactonization, leading to the production of 4.
