1239349-15-5

Basic information

• Product Name: 1-(cyclohexyloxycarbonyloxy)ethyl 2-bromo-3-(ethoxy(1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methylamino)methyleneamino)benzoate
• Synonyms: 1-(cyclohexyloxycarbonyloxy)ethyl 2-bromo-3-(ethoxy(1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methylamino)methyleneamino)benzoate
• CAS NO: 1239349-15-5
• Molecular Weight: 933.902
• Mol File: 1239349-15-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(cyclohexyloxycarbonyloxy)ethyl 2-bromo-3-(ethoxy(1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methylamino)methyleneamino)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(cyclohexyloxycarbonyloxy)ethyl 2-bromo-3-(ethoxy(1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methylamino)methyleneamino)benzoate(1239349-15-5)
• EPA Substance Registry System: 1-(cyclohexyloxycarbonyloxy)ethyl 2-bromo-3-(ethoxy(1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methylamino)methyleneamino)benzoate(1239349-15-5)

Safety Data

• Hazardous Substances Data: 1239349-15-5(Hazardous Substances Data)

Upstream product

• 1239349-13-3 methyl 2-bromo-3-(ethoxy(1-(2'-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl)methylamino)methyleneamino)benzoate 
• 99464-83-2 1-chloroethyl cyclohexyl carbonate 
• 1239349-14-4 2-bromo-3-(ethoxy(1-(2'-(1-trityl-1H-tetrazol-5-yl)bi-phenyl-4-yl)methylamino)methyleneamino)benzoic acid 

Downstream Products

• 170791-09-0 cilexetil trityl candesartan 

Relevant articles and documents

A noveland practical synthesis of substituted 2-ethoxy benzimidazole: Candesartan cilexetil

A novel and practical synthetic route for the preparation of candesartan cilexetil from methyl 2-amino-3-nitrobenzoate is described.The key steps are the reaction of methyl 2-bromo-3-(diethoxy-methyleneamino)benzoate with (2-(1-trityl-1H-tetrazol-5-yl) biphenyl-4-yl) methanamine and the final formation of 2-ethoxy benzimidazole ring via intramolecular N-arylation.The final ring closure process could be utilized to prepare other 2-substituted benzimidazoles.The method is simple for operation and suitable for industrial production.