123944-74-1Relevant academic research and scientific papers
(Aryloxy)methylsilane Derivatives as New Cholesterol Biosynthesis Inhibitors: Synthesis and Hypocholesterolemic Activity of a New Class of Squalene Epoxidase Inhibitors
Gotteland, Jean-Pierre,Brunel Isabelle,Gendre, Fabrice,Desire, Jerome,Delhon, Andre,at al.
, p. 3207 - 3216 (2007/10/03)
A series of 3-substituted (aryloxy)silane derivatives of benzylamine (4' 4', or 4") was synthesized and evaluated for hypocholesterolemic activity.Most of the new silane derivatives were identified as potent inhibitors of pig liver squalene epoxidase with
PROCESS FOR PRODUCING ENYNE DERIVATIVES
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, (2008/06/13)
A process for producing an enyne derivative, and intermediate, which is useful for preparing compounds showing strong inhibiting activities against squalane.e-poxidase of Eumycetes and strong anti-cholesterol ac-tivities. The process comprises reacting a compound of the formula:
