131060-14-5 Usage
General Description
NB-598 is a chemical compound that is primarily utilized in scientific research as a potent inhibitor of squalene monooxygenase, an important enzyme in the cholesterol biosynthesis pathway. By suppressing this enzyme, NB-598 can help to reduce the production of cholesterol in the body. NB-598 makes it possible for researchers to better understand the role of squalene monooxygenase and its pathophysiological implications, such as its contribution to many heart diseases and certain types of cancers.
Check Digit Verification of cas no
The CAS Registry Mumber 131060-14-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,1,0,6 and 0 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 131060-14:
(8*1)+(7*3)+(6*1)+(5*0)+(4*6)+(3*0)+(2*1)+(1*4)=65
65 % 10 = 5
So 131060-14-5 is a valid CAS Registry Number.
InChI:InChI=1/C27H31NOS2/c1-5-28(14-8-6-7-13-27(2,3)4)18-22-10-9-11-25(16-22)29-19-26-17-24(21-31-26)23-12-15-30-20-23/h6,8-12,15-17,20-21H,5,14,18-19H2,1-4H3/b8-6+
131060-14-5Relevant articles and documents
Comparative study of new and known thienyl derivatives of ene-yne benzylamine as mammalian squalene epoxidase inhibitors
Gotteland,Junquero,Oms,Delhon,Halazy
, p. 333 - 342 (2007/10/03)
Analogs of the well-known squalene epoxidase inhibitor (SE) NB-598 (2) have been prepared and tested as cholesterol biosynthesis inhibitors in HepG2 cells. Among the compounds tested, the vinylthiophene analog 4 and the tertiary amide derivative of thiophene 8 emerged as potent human SE inhibitors and probably bind to the enzyme in a very similar manner as NB-598 (2). Surprisingly enough, compounds 4 and 8, contrary to NB-598, are poor inhibitors of rat SE, thus further demonstrating major differences between mammalian enzymes from different species.
