1239470-62-2

Basic information

• Product Name: (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(morpholino)methanone
• Synonyms: (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(morpholino)methanone
• CAS NO: 1239470-62-2
• Molecular Weight: 291.737
• Mol File: 1239470-62-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(morpholino)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(morpholino)methanone(1239470-62-2)
• EPA Substance Registry System: (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(morpholino)methanone(1239470-62-2)

Safety Data

• Hazardous Substances Data: 1239470-62-2(Hazardous Substances Data)

Upstream product

• 39757-35-2 methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate 
• 79508-09-1 methyl 3‐(4‐chlorophenyl)‐1H‐pyrazole‐5‐carboxylate 
• 99-91-2 para-chloroacetophenone 
• 110-91-8 morpholine 
• 54006-63-2 3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid 

Relevant articles and documents

Pyrazole derivatives as inhibitors of arachidonic acid-induced platelet aggregation

Antiplatelet drugs are promising therapeutics to intervene with platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischemic stroke. Here, we describe the synthesis and structure-activity relationships of potent inhibitors of platelet aggregation based on the 1,5-diarylpyrazol-3-carboxamide scaffold. Analogs from this series demonstrated potent anti-aggregatory activities against arachidonic acid-induced platelet aggregation, as measured by turbidimetric method of Born. 1,5-Diarylpyrazole-3- carboxamides obtained with small-basic amines (7, 8, 50, 51, 61, 62) displayed the strongest activity with IC50 values in low nanomolar range (5.7-83 nM). On the basis of their high potency in cellular environment, these straightforward pyrazole derivatives may possess potential in the design of more potent compounds for intervention with cardiovascular diseases.