79508-09-1

Usage

Uses

Used in Pharmaceutical Research:
3-carbomethoxy-5-(4-chlorophenyl)pyrazole is used as a potential therapeutic agent for the development of new drugs to treat a range of diseases. Its specific pharmacological properties and potential applications are under investigation in scientific studies and research, which recognize its promising role in drug development.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 3-carbomethoxy-5-(4-chlorophenyl)pyrazole is employed for its unique structure and properties, which contribute to its potential as a building block or active component in the creation of novel pharmaceutical compounds.
Used in Materials Science and Chemical Synthesis:
Beyond its applications in medicine, 3-carbomethoxy-5-(4-chlorophenyl)pyrazole may also find uses in other fields such as materials science and chemical synthesis, where its chemical properties could be leveraged for various purposes.

Upstream product

• 1345876-68-7 (E)-methyl 4-(4-chlorophenyl)-2-diazobut-3-enoate 
• 1250907-72-2 methyl (E)-4-(4-chlorophenyl)but-3-enoate 
• 104-88-1 4-chlorobenzaldehyde 
• 127404-70-0 (E)-4-(4-chlorophenyl)-3-butenoic acid 
• 99-91-2 para-chloroacetophenone 
• 39757-35-2 methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate 

Downstream Products

• 36640-69-4 1-(2-methyl-N-phenylbenzimidoyl)-3-carbomethoxy-5-(4-chlorophenyl)pyrazole 
• 36664-36-5 5-(4-chloro-phenyl)-1-(N-phenyl-benzimidoyl)-1H-pyrazole-3-carboxylic acid methyl ester 
• 36664-37-6 5-(4-chloro-phenyl)-1-(N-cyclohexyl-benzimidoyl)-1H-pyrazole-3-carboxylic acid methyl ester 
• 1239470-62-2 (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(morpholino)methanone 
• 1443777-93-2 (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone 
• 1443777-94-3 (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(morpholino)methanone 
• 54006-63-2 3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid 
• 1015868-48-0 1-methyl-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid 
• 1353725-69-5 C₁₁H₈Cl₂N₂O 
• 1135147-90-8 (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(piperidin-1-yl)methanone 
• 1391108-14-7 methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate 
• 36664-34-3 5-(4-chloro-phenyl)-1-[N-(4-methoxy-phenyl)-benzimidoyl]-1H-pyrazole-3-carboxylic acid methyl ester 
• 36664-35-4 5-(4-chloro-phenyl)-1-(4-methyl-N-p-tolyl-benzimidoyl)-1H-pyrazole-3-carboxylic acid methyl ester 
• 79508-04-6 5-(4-Chloro-phenyl)-1-{[(Z)-4-chloro-phenylimino]-phenyl-methyl}-1H-pyrazole-3-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Design, synthesis, biological evaluation and in silico studies of pyrazole‐based nh2‐acyl oseltamivir analogues as potent neuraminidase inhibitors

Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti‐influenza therapy. The 150‐cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150‐cavity

Intramolecular Cyclization of Vinyldiazoacetates as a Versatile Route to Substituted Pyrazoles

Vinyldiazo compounds undergo a thermal electrocyclization to form pyrazoles in yields of up to 95percent. The reactions are operationally simple, use readily available starting materials, require no intervention of a catalyst, and enable the synthesis of mono-, di- A nd tri-substituted pyrazoles. With the ability to produce highly substituted pyrazoles and the flexibility in installing various types of substituents, this method constitutes a new entry to this valuable heterocyclic scaffold and may be of interest to all branches of the chemical industry.

Pyrazole derivatives as inhibitors of arachidonic acid-induced platelet aggregation

Antiplatelet drugs are promising therapeutics to intervene with platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischemic stroke. Here, we describe the synthesis and structure-activity relationships of potent inhibitors of platelet aggregation based on the 1,5-diarylpyrazol-3-carboxamide scaffold. Analogs from this series demonstrated potent anti-aggregatory activities against arachidonic acid-induced platelet aggregation, as measured by turbidimetric method of Born. 1,5-Diarylpyrazole-3- carboxamides obtained with small-basic amines (7, 8, 50, 51, 61, 62) displayed the strongest activity with IC50 values in low nanomolar range (5.7-83 nM). On the basis of their high potency in cellular environment, these straightforward pyrazole derivatives may possess potential in the design of more potent compounds for intervention with cardiovascular diseases.