79508-09-1

Basic information

• Product Name: 3-carbomethoxy-5-(4-chlorophenyl)pyrazole
• Synonyms: 3-carbomethoxy-5-(4-chlorophenyl)pyrazole
• CAS NO: 79508-09-1
• Molecular Formula: C₁₁H₉ClN₂O₂
• Molecular Weight: 236.65436
• EINECS: -0
• Mol File: 79508-09-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 446.0±35.0 °C(Predicted)
• Appearance: /
• Density: 1.343±0.06 g/cm3(Predicted)
• PKA: 9.84±0.10(Predicted)
• CAS DataBase Reference: 3-carbomethoxy-5-(4-chlorophenyl)pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-carbomethoxy-5-(4-chlorophenyl)pyrazole(79508-09-1)
• EPA Substance Registry System: 3-carbomethoxy-5-(4-chlorophenyl)pyrazole(79508-09-1)

Safety Data

• Hazardous Substances Data: 79508-09-1(Hazardous Substances Data)

Usage

General Description

3-carbomethoxy-5-(4-chlorophenyl)pyrazole is a chemical compound with the molecular formula C11H10ClN3O2. It is a pyrazole derivative that contains a carbomethoxy group and a 4-chlorophenyl group. 3-carbomethoxy-5-(4-chlorophenyl)pyrazole is often used in medicinal chemistry and pharmaceutical research as a potential therapeutic agent, particularly in the development of new drugs for the treatment of various diseases. Its specific pharmacological properties and potential applications have been the subject of scientific studies and research, and it is considered to have significant potential in drug development due to its unique structure and properties. Additionally, the compound may also have uses in other fields such as materials science and chemical synthesis.

Upstream product

• 39757-35-2 methyl 4-(4-chlorophenyl)-2,4-dioxobutanoate 
• 99-91-2 para-chloroacetophenone 
• 127404-70-0 (E)-4-(4-chlorophenyl)-3-butenoic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 1250907-72-2 methyl (E)-4-(4-chlorophenyl)but-3-enoate 
• 1345876-68-7 (E)-methyl 4-(4-chlorophenyl)-2-diazobut-3-enoate 

Downstream Products

• 36640-69-4 1-(2-methyl-N-phenylbenzimidoyl)-3-carbomethoxy-5-(4-chlorophenyl)pyrazole 
• 36664-36-5 5-(4-chloro-phenyl)-1-(N-phenyl-benzimidoyl)-1H-pyrazole-3-carboxylic acid methyl ester 
• 1239470-62-2 (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(morpholino)methanone 
• 1443777-93-2 (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(piperidin-1-yl)methanone 
• 1443777-94-3 (3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl)(morpholino)methanone 
• 54006-63-2 3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid 
• 1015868-48-0 1-methyl-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid 
• 1353725-69-5 C₁₁H₈Cl₂N₂O 
• 1135147-90-8 (3-(4-chlorophenyl)-1H-pyrazol-5-yl)(piperidin-1-yl)methanone 
• 1391108-14-7 methyl 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-carboxylate 
• 36664-37-6 5-(4-chloro-phenyl)-1-(N-cyclohexyl-benzimidoyl)-1H-pyrazole-3-carboxylic acid methyl ester 
• 36664-35-4 5-(4-chloro-phenyl)-1-(4-methyl-N-p-tolyl-benzimidoyl)-1H-pyrazole-3-carboxylic acid methyl ester 
• 79508-04-6 5-(4-Chloro-phenyl)-1-{[(Z)-4-chloro-phenylimino]-phenyl-methyl}-1H-pyrazole-3-carboxylic acid methyl ester 
• 79508-01-3 5-(4-Chloro-phenyl)-1-[[(Z)-cyclohexylimino]-(2-methoxy-phenyl)-methyl]-1H-pyrazole-3-carboxylic acid methyl ester 

Relevant articles and documents

Design, synthesis, biological evaluation and in silico studies of pyrazole‐based nh2‐acyl oseltamivir analogues as potent neuraminidase inhibitors

Oseltamivir represents one of the most successful neuraminidase (NA) inhibitors in the current anti‐influenza therapy. The 150‐cavity of NA was identified as an additional binding pocket, and novel NA inhibitors have been designed to occupy the 150‐cavity

Pyrazole derivatives as inhibitors of arachidonic acid-induced platelet aggregation

Antiplatelet drugs are promising therapeutics to intervene with platelet aggregation in arterial thrombosis, most prominently in myocardial infarction and ischemic stroke. Here, we describe the synthesis and structure-activity relationships of potent inhibitors of platelet aggregation based on the 1,5-diarylpyrazol-3-carboxamide scaffold. Analogs from this series demonstrated potent anti-aggregatory activities against arachidonic acid-induced platelet aggregation, as measured by turbidimetric method of Born. 1,5-Diarylpyrazole-3- carboxamides obtained with small-basic amines (7, 8, 50, 51, 61, 62) displayed the strongest activity with IC50 values in low nanomolar range (5.7-83 nM). On the basis of their high potency in cellular environment, these straightforward pyrazole derivatives may possess potential in the design of more potent compounds for intervention with cardiovascular diseases.