123949-01-9 Usage
Uses
Different sources of media describe the Uses of 123949-01-9 differently. You can refer to the following data:
1. (4S)-10-(Ethoxymethyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity.
2. (4S)-10-(Ethoxymethyl)-4-ethyl-4,9-dihydroxy-1H-pyrano[3'',4'':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione is an intermediate in the synthesis of Camptothecin analogs for the inhibition of topoisomerase I and antitumor activity.
Check Digit Verification of cas no
The CAS Registry Mumber 123949-01-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,4 and 9 respectively; the second part has 2 digits, 0 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 123949-01:
(8*1)+(7*2)+(6*3)+(5*9)+(4*4)+(3*9)+(2*0)+(1*1)=129
129 % 10 = 9
So 123949-01-9 is a valid CAS Registry Number.
123949-01-9Relevant articles and documents
The solvolysis of topotecan in alcohols and acetic anhydride
Li, Jiajun,Wang, Guolin,Dong, Mengjie,Zhang, Qian
scheme or table, p. 2324 - 2326 (2011/06/17)
Six derivatives of 10-hydroxycamptothecin were prepared via solvolysis of topotecan in corresponding alcohols and acetic anhydride. We attributed the specific reactivity of topotecan to the internal hydrogen-bonding between 10-hydroxy and the nitrogen atom in position 9. As a result the reaction underwent through an intermediate ortho-quionomethlide species to reach equilibrium. Bioactivity screening data showed all products could potentially inhibit the proliferation of several cancer cell lines in vitro and a bigger size group in 9-position would be favorable for the anti-tumor activities observably.
