123953-16-2Relevant articles and documents
New antibacterial agents: Hybrid bioisoster derivatives as potential E. coli FabH inhibitors
Segretti, Natanael D.,Serafim, Ricardo A.M.,Segretti, Mariana C.F.,Miyata, Marcelo,Coelho, Fernando R.,Augusto, Ohara,Ferreira, Elizabeth I.
, p. 3988 - 3993 (2016)
The development of resistance to antibiotics by microorganisms is a major problem for the treatment of bacterial infections worldwide, and therefore, it is imperative to study new scaffolds that are potentially useful in the development of new antibiotics
Synthesis and characterization of a new family of energetic salts based on guanidinium cation containing furoxanyl functionality
Wu, Bo,Wang, Zhixin,Yang, Hongwei,Lin, Qiuhan,Ju, Xuehai,Lu, Chunxu,Cheng, Guangbin
, p. 58243 - 58251 (2014)
A new family of energetic salts based on a new guanidinium cation containing furoxanyl functionality, 1-(3′-methylfuroxanyl)methyleneamino guanidinium cation, were synthesized and well characterized by IR and multinuclear NMR spectroscopy, elemental analysis as well as differential scanning calorimetry. The structures of salts 1, 4, 5 and 6 were confirmed by single-crystal X-ray diffraction. Most of the salts decompose at temperatures over 180 °C. Furthermore, except for salts 7 and 9, the remaining energetic salts exhibit low impact sensitivities (15-40 J), friction sensitivities (120-360 N), and are insensitive to electrostatics. The detonation pressure values calculated for these salts range from 19.3 to 27.5 GPa, and the detonation velocities range from 7515 to 8402 m s-1. These results make some energetic salts potential candidates for energetic materials with good thermal stabilities and low sensitivities. This journal is
Synthesis and preliminary evaluation of N-oxide derivatives for the prevention of atherothrombotic events
Rosseto, Leandro Augusto,Pires, Maria Elisa Lopes,Melchior, Aylime Castanho Bolognesi,Bosquesi, Priscila Longhin,Pavan, Aline Renata,Marcondes, Sisi,Chung, Man Chin,Dos Santos, Jean Leandro
, p. 18185 - 18200 (2015)
Thrombosis is the main outcome of many cardiovascular diseases. Current treatments to prevent thrombotic events involve the long-term use of antiplatelet drugs. However, this therapy has several limitations, thereby justifying the development of new drugs
In Vitro Metabolic Stability and in Vivo Biodistribution of 3-Methyl-4-furoxancarbaldehyde Using PET Imaging in Rats
Pippin, Adam B.,Mohd Arshad, Zaira Hidayah,Voll, Ronald J.,Nye, Jonathon A.,Ghassabian, Sussan,Williams, Craig M.,Mancini, Alessandra,Liotta, Dennis C.,Smith, Maree T.,Goodman, Mark M.
, p. 563 - 567 (2016)
Painful diabetic neuropathy (PDN) is a type of peripheral neuropathic pain that is currently difficult to treat using clinically available analgesics. Recent work suggests a progressive depletion of nitric oxide (NO) in nerve cells may be responsible for the pathobiology of PDN. The nitric oxide donor, 3-methyl-4-furoxancarbaldehyde (PRG150), has been shown to produce dose-dependent analgesia in a rat model of PDN. To gain insight into the mechanism of analgesia, methods to radiolabel PRG150 were developed to assess the in vivo biodistribution in rats. The furoxan ring was labeled with 13N to follow any nitric oxide release and the 3-methyl substituent was labeled with 11C to track the metabolite using PET imaging. The in vitro metabolic stability of PRG150 was assessed in rat liver microsomes and compared to in vivo metabolism of the synthesized radiotracers. PET images revealed a higher uptake of 13N over 11C radioactivity in the spinal cord. The differences in radioactive uptake could indicate that a NO release in the spinal cord and other components of the somatosensory nervous system may be responsible for the analgesic effects of PRG150 seen in the rat model of PDN.
Schiff bases containing a furoxan moiety as potential nitric oxide donors in plant tissues
Georgescu, Emilian,Oancea, Anca,Georgescu, Florentina,Nicolescu, Alina,Oprita, Elena Iulia,Vladulescu, Lucian,Vladulescu, Marius-Constantin,Oancea, Florin,Shova, Sergiu,Deleanu, Calin
, (2018)
Stable Schiff bases containing a furoxan moiety are synthesized as single regioisomers by the reaction of 3-methyl-2-oxy-furazan-4-carbaldehydewith various amino compounds at room temperature. The structures of synthesized compounds were fully characterized by multinuclear NMR spectroscopy and X-ray crystallography. The effect of synthesized Schiff bases containing a furoxan moiety on biological generation of reactive oxygen species and nitric oxide in plant tissues was investigated for the first time by fluorescence microscopy and the released NO identified as nitrite with Griess reagent. There is a good correlation between the biological generation of NO determined by fluorescence microscopy and with Griess reagent. Some of the synthesized compounds exhibited both nitric oxide and reactive oxygen species generation abilities and represent potential NO donors in plant tissues.
Synthesis and biological evaluation of some new furoxan derivatives as anti-inflammatory agents
Amir, Mohd,Verma, Jeevan S.,Tariq, Sana,Somakala,Ehtaishamul Haq
, p. 955 - 959 (2019/05/21)
A new series of furoxan derivatives (3a-k) have been synthesized and characterized by their IR, 1H NMR and mass spectral data. All the compounds have been screened for their anti-inflammatory activity. The compounds 3a, 3b, 3f, 3g, and 3i which show significant anti-inflammatory activity have been further studied for their ulcerogenic activities and nitric oxide releasing properties. Furoxan derivative 3-memyl-4-[{2-(2-phenylacetyl)hydrazono}memyl]-furoxan 3f showed greater anti-inflammatory activity comparable to standard drug ibuprofen. The compound also showed reduced, ulcerogenicity and high nitric oxide releasing properties.
