123955-10-2 Usage
General Description
Almokalant is a class III anti-arrhythmic agent that acts as a selective blocker of the delayed rectifier potassium current in cardiac myocytes. It is used in the treatment of atrial fibrillation/flutter and other cardiac arrhythmias by prolonging the action potential duration and refractory period of the heart. Almokalant works by binding to and blocking the potassium channels in the heart muscle cells, thereby preventing the rapid repolarization that can lead to abnormal heart rhythms. However, its use is limited due to its potential for causing life-threatening ventricular arrhythmias, and it is primarily used for research purposes in studying cardiac electrophysiology and arrhythmias.
Check Digit Verification of cas no
The CAS Registry Mumber 123955-10-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,2,3,9,5 and 5 respectively; the second part has 2 digits, 1 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 123955-10:
(8*1)+(7*2)+(6*3)+(5*9)+(4*5)+(3*5)+(2*1)+(1*0)=122
122 % 10 = 2
So 123955-10-2 is a valid CAS Registry Number.
InChI:InChI=1/C18H28N2O3S/c1-3-11-24(22)12-5-10-20(4-2)14-17(21)15-23-18-8-6-16(13-19)7-9-18/h6-9,17,21H,3-5,10-12,14-15H2,1-2H3
123955-10-2Relevant articles and documents
Polystyrenesulfonate-drug complex and solid dosage forms thereof
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, (2008/06/13)
Almokalant (p-INN), 4-[3-]ethyl[3-(propylsulfinyl)propyl]amino[-2-hydroxypropoxy]-benzonitrile, having the formula STR1 is a member of a group of compounds useful in the treatment of cardiac arrhythmias. Enhanced stability, palatability, and technical pro
Stereoisomers of benzonitrile derivatives, useful as cardiac arrhythmiac agents
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, (2008/06/13)
4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-((S*)-propylsulfinyl)propyl]amino]-2(R)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-((R*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzonitrile, 4-[3-[ethyl[3-[((S*)-propylsulfinyl)propyl]amino]-2(S)-hydroxypropoxy]-benzonitrile and pharmaceutically acceptable salt thereof, processes for their preparation, as well as the use of said compounds for the preparation of medicaments with action against cardiac arrhythmias.
