1239587-68-8

Basic information

• Product Name: 4-MaleiMidobutyric Acid Hydrazide Trifluoroacetate
• Synonyms: 4-MaleiMidobutyric Acid Hydrazide Trifluoroacetate;2,5-Dihydro-2,5-dioxo-1H-Pyrrole-1-butanoic Acid Hydrazide 2,2,2-Trifluoroacetate;4-MaleiMidobutyric acid hydrazide trifluoroacetic acid salt
• CAS NO: 1239587-68-8
• Molecular Formula: C10H12F3N3O5
• Molecular Weight: 311.2145896
• Product Categories: Heterocycles;Intermediates;Maleimide Derivatives;MTS & Sulfhydryl Active Reagents
• Mol File: 1239587-68-8.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-MaleiMidobutyric Acid Hydrazide Trifluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: 4-MaleiMidobutyric Acid Hydrazide Trifluoroacetate(1239587-68-8)
• EPA Substance Registry System: 4-MaleiMidobutyric Acid Hydrazide Trifluoroacetate(1239587-68-8)

Safety Data

• Hazardous Substances Data: 1239587-68-8(Hazardous Substances Data)

Usage

Uses

4-MaleiMidobutyric Acid Hydrazide Trifluoroacetate is a maleimide derivative used as a reagent in the preparation of immunoenzymic conjugates.

Upstream product

• 57078-98-5 4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoic acid 
• 80307-12-6 4-maleimidobutyric acid N-hydroxysuccinimide ester 
• 76-05-1 trifluoroacetic acid 
• 1239587-67-7 tert-butyl 2-(4-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)butanoyl)hydrazinecarboxylate 

Relevant articles and documents

CYTOTOXIC-DRUG DELIVERING MOLECULES TARGETING HIV (CDM-HS), CYTOTOXIC ACTIVITY AGAINST THE HUMAN IMMUNODEFICIENCY VIRUS AND METHODS OF USE

The present invention is directed to new bifunctional compounds and methods for treating HIV infections. The bifunctional small molecules, generally referred to as CDM-Hs, function through orthogonal pathways, by inhibiting the gp120-CD4 interaction, and by introducing cytotoxic moieties to gp120-expressing cells, thereby causing cell death and preventing cell infection and spread of HIV. It is shown that CDM-Hs bind to gp120 and gp-120 expressing cells competitively with CD4, and these compounds cause cell death of HIV-infected cells, thereby decreasing viral infectivity. Compounds and methods are described herein.